Abstract Treatment outcomes for major depressive disorder (MDD) need to be improved.
Presently, no clinically relevant tools have been established for stratifying subgroups or …

Background Many depressed patients are not able to achieve or sustain symptom remission
despite serial treatment trials–often termed “treatment resistant depression”. A broader …

Background A patient is considered to suffer from treatment resistant depression (TRD)
when consecutive treatment with two products of different pharmacological classes, used for …

OBJECTIVE: Our objective was to synthesize observational studies examining the
association of physical activity in childhood and adolescence with depression. DATA …

Objectives: The overview outlines two decades of research from the European Group for the
Study of Resistant Depression (GSRD) that fundamentally impacted evidence-based …

Background Clear guidance for successive antidepressant pharmacological treatments for
non-responders in major depression is not well established. Method Based on the …

Objectives Clinical variables were investigated in the 'treatment resistant depression (TRD)‐
III'sample to replicate earlier findings by the European research consortium 'Group for the …

Abstract Treatment resistance to the antidepressive pharmacotherapy represents one of the
most important clinical challenges in the pharmacological management of unipolar …

Objective: Clinical trials demonstrated that ketamine exhibits rapid antidepressant efficacy
when administered in subanaesthetic dosages. We reviewed currently available literature …

This naturalistic European multicenter study aimed to elucidate the association between
major depressive disorder (MDD) and comorbid anxiety disorders. Demographic and clinical …