Background: Out of 3 billion base pairs in human genome only~ 2% code for proteins; and
out of 180,000 transcripts in human cells, about 20,000 code for protein, remaining 160,000 …

In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of
many cytosine residues to 5-methylcytosine. For several years, control of gene activity by …

MicroRNA (miRNA) have gained widespread attention for their role in diverse vascular
processes including angiogenesis, apoptosis, proliferation, and migration. Despite great …

METHODS AND RESULTS We reviewed the notes of 149 BWS patients who had been
referred to the BWS Research Group at the Birmingham University Section of Medical …

Background Hyperhomocysteinaemia occurs in several genetically determined and
acquired disorders and is highly prevalent in patients with uraemia. In these disorders …

▪ Abstract A handful of autosomal genes in the mammalian genome are inherited in a silent
state from one of the two parents, and in a fully active form from the other, thereby rendering …

Abstract Changes in DNA methylation profiles are common features of development and in a
number of human diseases, such as cancer and imprinting disorders like Beckwith …

Genomic imprinting refers to an epigenetic marking of genes that results in monoallelic
expression. This parent-of-origin dependent phenomenon is a notable exception to the laws …

Loss of imprinting at IGF2, generally through an H19-independent mechanism, is associated
with a large percentage of patients with the overgrowth and cancer predisposition condition …

Sporadic persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or nesidioblastosis is
a heterogeneous disorder characterized by profound hypoglycemia due to inappropriate …