The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …

In mammals, the insulin receptor (IR) gene has acquired an additional exon, exon 11. This
exon may be skipped in a developmental and tissue-specific manner. The IR, therefore …

ContextDiabetes is a serious and costly disease that is becoming increasingly common in
many countries. The role of diabetes as a cancer risk factor remains unclear. ObjectiveTo …

4. Dr. Gregory Kaltsas MD FRCP (Lon) is a Professor in General Medicine and
Endocrinology at the National and Kapodistrian University of Athens, Greece. He was …

Abstract Sirtuins (SIRTs 1− 7), or class III histone deacetylases (HDACs), are protein
deacetylases/ADP ribosyltransferases that target a wide range of cellular proteins in the …

Background: Studies investigating the association between diabetes mellitus and prostate
cancer have reported inconsistent findings. We examined this association by conducting a …

Carrying excess body fat is a leading cause of cancer. Epidemiologic evidence gives strong
clues about the mechanisms that link excess adiposity to risk for several cancer sites. For …

Insulin and insulin-like growth factor (IGF) signaling system, commonly known for fine-tuning
numerous biological processes, has lately made its mark as a much sought-after therapeutic …

OBJECTIVE—To investigate whether hyperglycemia is associated with increased cancer
risk. RESEARCH DESIGN AND METHODS—In the Västerbotten Intervention Project of …

Aims/hypothesis The association of diabetes mellitus with prostate cancer has been
controversial. This study examines the strength of this association by conducting a detailed …