Drugs to prevent malaria in pregnancy are not recommended during the first trimester in
high-transmission areas. Poor outcomes associated with infections in early pregnancy …

Background Malaria is the disease caused by Plasmodium species and primarily transmitted
by the bite of female Anopheles mosquitoes. During pregnancy, malaria causes life …

Background The gametocyte stage of Plasmodium falciparum is considered an important
target for disrupting malaria transmission. Indications are that various demographic groups …

Background During early pregnancy, the placenta develops to meet the metabolic demands
of the foetus. The objective of this analysis was to examine the effect of malaria parasitaemia …

Background Parasitic infection (s) during pregnancy have been associated with increased
risk of pregnancy complications and adverse outcomes in low resource settings. However …

Background Plasmodium vivax infections seldom kill directly but do cause indirect mortality
by reducing birth weight and causing abortion. Cytoadherence and sequestration in the …

Every year, millions of people are infected with malaria, resulting in significant economic
losses to the developing and developed nations. The malaria parasite pursues a …

Abstract Triazole tethered 7-chloroquinoline-pyrimidine-5-carboxylate hybrids were
synthesized and evaluated for antiplasmodial activity against chloroquine sensitive (CQ S) …

Background In individuals living in malaria-endemic regions, parasitaemia thresholds for the
onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate …

Host immunity is an important but poorly understood determinant of antimalarial efficacy,
influencing the outcome of prevention and treatment trials. Variations in host immunity might …