Cataract is a visible opacity in the lens substance, which, when located on the visual axis,
leads to visual loss. Age-related cataract is a cause of blindness on a global scale involving …

Cataracts or clouding of the lens is the leading cause of blindness in the world. Age and
diabetes are major risk factors, and with an increasing aging and diabetic population, the …

Intracellular proteins with long lifespans have recently been linked to age-dependent
defects, ranging from decreased fertility to the functional decline of neurons. Why long-lived …

The Greenland shark (Somniosus microcephalus), an iconic species of the Arctic Seas,
grows slowly and reaches> 500 centimeters (cm) in total length, suggesting a life span well …

Protein turnover is an effective way of maintaining a functional proteome, as old and
potentially damaged polypeptides are destroyed and replaced by newly synthesized copies …

The ocular lens is a model system for understanding important aspects of embryonic
development, such as cell specification and the spatiotemporally controlled formation of a …

The lens of the eye has long been considered as a radiosensitive tissue, but recent research
has suggested that the radiosensitivity is even greater than previously thought. The 2012 …

Purpose To assess the utility of integrating genomic data from next-generation sequencing
and phenotypic data to enhance the diagnosis of bilateral congenital cataract (CC). Design …

Ocular lens development represents an advantageous system in which to study regulatory
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …

The optical properties of the ocular lens are important to overall vision quality. As a
transparent biological tissue, the lens contributes to the overall and dynamic focussing …