Activation of transcription factor NF-κB is frequently encountered in tumor cells and
contributes to aggressive tumor growth and resistance to chemotherapy and ionizing …

The treatment of cancer with chemotherapeutic agents and radiation has two major
problems: time-dependent development of tumor resistance to therapy (chemoresistance …

BACKGROUND The cyclooxygenase (COX) enzyme catalyzes the formation of
prostaglandins, which can affect cell proliferation and alter the response of the immune …

Abstract Cyclooxygenase-2 (COX-2) is expressed within neovascular structures that support
many human cancers. Inhibition of COX-2 by celecoxib delays tumor growth and metastasis …

Objective To examine cyclooxygenase‐2 (COX‐2) enzyme expression, its regulation by
interleukin‐1β (IL‐1β), and the role of prostaglandin E2 (PGE2) in proteoglycan degradation …

In addition to the well-established pathophysiological role that COX-2 plays in inflammation,
recent evidence implies that this isoform may also be involved in multiple biologic events …

The aggressive biology of human pancreatic adenocarcinoma has been linked with
overexpression of vascular endothelial growth factor (VEGF). Constitutive activation of the …

Epidemiological studies have shown that nonsteroidal anti-inflammatory drugs (NSAIDs)
may have a role in the prevention of human cancers. A number of preclinical studies have …

It has been hypothesized that cyclooxgenase 2 specific inhibitors may increase the risk of
cardiovascular (CV) thromboembolic events because of their inhibition of vascular …

Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic
acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed …