There is an enormous global public health burden due to antimicrobial-resistant (AMR)
Klebsiella pneumoniae high-risk clones. K. pneumoniae ST307 and ST147 are recent …

The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat
to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant …

Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in
1996. Since then, these versatile β-lactamases have spread internationally among Gram …

The spread of carbapenemase producers in Enterobacteriaceae has now been identified
worldwide. Three main carbapenemases have been reported; they belong to three classes …

In 2012, the European Centre for Disease Prevention and Control (ECDC) launched the
'European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE)'project to …

Antimicrobial-resistant Klebsiella pneumoniae (Kp) has emerged as a major global public
health problem. While resistance can occur across a broad range of Kp clones, a small …

The rapidity with which new types of antibiotic resistance can disseminate globally following
their initial emergence or recognition is exemplified by the novel carbapenemase New Delhi …

Carbapenems, once considered the last line of defense against of serious infections with
Enterobacteriaceae, are threatened with extinction. The increasing isolation of carbapenem …

Bacterial resistance to antibiotics has become a major source of concern for public health.
Enterobacteriaceae are among the most common human pathogens, causing community …

Carbapenems (imipenem, meropenem, biapenem, ertapenem, and doripenem) are β-
lactam antimicrobial agents. Because carbapenems have the broadest spectra among all β …