In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …

Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …

Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …

The gut microbiota has been linked to the development of obesity and type 2 diabetes (T2D).
The underlying mechanisms as to how intestinal microbiota may contribute to T2D are only …

Antibody therapies have become an important class of therapeutics in recent years as they
have exhibited outstanding efficacy and safety in the treatment of several major diseases …

Periodontitis is a chronic inflammatory condition of the periodontium involving interactions
between bacterial products, numerous cell populations and inflammatory mediators. It is …

Psoriasis is a chronic systemic inflammatory disease causing erythematosus and scaly skin
plaques; up to 30% of patients with psoriasis develop Psoriatic Arthritis (PsA), which is …

Pyoderma gangrenosum is a challenging skin condition to identify and treat because of its
multifactorial pathogenesis. It is a rare cutaneous manifestation diagnosed clinically by …

Cytokines, produced at the site of entry of a pathogen, drive inflammatory signals that
regulate the capacity of resident and newly arrived phagocytes to destroy the invading …