Oleate restores altered autophagic flux to rescue palmitate lipotoxicity in hypothalamic neurons

W He, A Tran, CT Chen, N Loganathan… - Molecular and Cellular …, 2022 - Elsevier
Accumulation of excess lipids in non-adipose tissues, such as the hypothalamus, is termed
lipotoxicity and causative of free fatty acid-mediated pathology in metabolic disease. This …

Childhood obesity is linked to putative neuroinflammation in brain white matter, hypothalamus, and striatum

ZA Li, A Samara, MK Ray, J Rutlin… - Cerebral Cortex …, 2023 - academic.oup.com
Neuroinflammation is both a consequence and driver of overfeeding and weight gain in
rodent obesity models. Advances in magnetic resonance imaging (MRI) enable …

Brain region changes following a spinal cord injury

Z Wu, K Feng, J Huang, X Ye, R Yang, Q Huang… - Neurochemistry …, 2024 - Elsevier
Brain-related complications are common in clinical practice after spinal cord injury (SCI);
however, the molecular mechanisms of these complications are still unclear. Here, we …

[HTML][HTML] The Involvement of the microRNAs miR-466c and miR-340 in the Palmitate-Mediated Dysregulation of Gonadotropin-Releasing Hormone Gene Expression

V Nkechika, N Zhang, DD Belsham - Genes, 2024 - mdpi.com
Diets high in saturated fatty acids are associated with obesity and infertility. Palmitate, the
most prevalent circulating saturated fatty acid, is sensed by hypothalamic neurons …

Neuroendocrine microRNAs linked to energy homeostasis: Future therapeutic potential

KWY Mak, AF Mustafa, DD Belsham - Pharmacological Reports, 2022 - Springer
The brain orchestrates whole-body metabolism through an intricate system involving
interneuronal crosstalk and communication. Specifically, a key player in this complex …

[HTML][HTML] Supplementation with CO induces lipogenesis in adipose tissue, leptin and insulin resistance in healthy Swiss mice

ACC Veras, L da Silva Bruzasco, ABP Lopes… - Journal of Functional …, 2023 - Elsevier
The consumption of saturated fatty acids (SFA), the main compound in coconut oil (CO), can
promote insulin and leptin resistance and are associated with inflammation and obesity. We …

[HTML][HTML] Molecular Genetics of Rare Growth and Puberty Disorders in Finland

AP Iivonen - 2022 - helda.helsinki.fi
Growth and pubertal development are complex and interconnected processes, disruption of
which leads to abnormal development of the adult height or secondary sexual …

[PDF][PDF] Mécanismes régissant les effets bénéfiques des chirurgies bariatriques hypoabsorptives. Rôle du microbiote intestinal et des déterminants gastro-intestinaux …

P Mukorako - 2022 - corpus.ulaval.ca
Résumé L'obésité est une maladie complexe qui cause de nombreux troubles
physiopathologiques. La chirurgie bariatrique représente le meilleur traitement connu à ce …

AKTIVASI HIPOTALAMUS PADA KETAHANAN KELUARGA SEBAGAI ALARMING SYSTEM PENCEGAHAN MARITAL RAPE PERSPEKTIF NEUROSCIENCE DAN …

CZ Putri - repository.uinjkt.ac.id
Tesis ini ditulis dengan tujuan untuk menganalisis hubungan aktivasi hipotalamus dengan
hak dan kewajiban dalam berumah tangga, menganalisis aktivasi hipotalamus yang …