[HTML][HTML] Physiologically based pharmacokinetic (PBPK) modelling of oral drug absorption in older adults–an AGePOP review

C Demeester, D Robins, AE Edwina, J Tournoy… - European Journal of …, 2023 - Elsevier
The older population consisting of persons aged 65 years or older is the fastest-growing
population group and also the major consumer of pharmaceutical products. Due to the …

An update on medication use in older adults: a narrative review

HE Barry, CM Hughes - Current Epidemiology Reports, 2021 - Springer
Abstract Purpose of Review The global phenomenon of population aging is impacting the
health and care needs of society. The use of medications by older adults is acknowledged to …

Sex differences in multimorbidity and polypharmacy trends: a repeated cross-sectional study of older adults in Ontario, Canada

CJ Maxwell, L Mondor, AJ Pefoyo Koné, DB Hogan… - PloS one, 2021 - journals.plos.org
Background Multimorbidity is increasing among older adults, but the impact of these recent
trends on the extent and complexity of polypharmacy and possible variation by sex remains …

The association of potentially inappropriate medications, polypharmacy and anticholinergic burden with readmission and emergency room revisit after discharge: A …

CK Liang, MY Chou, YH Hsu, YC Wang… - British Journal of …, 2023 - Wiley Online Library
Aims While certain drug‐use indicators are known to be associated with clinical outcomes,
the relationship is unclear for some highly prevalent conditions in in patients aged≥ 65 …

Prevalence of prescription and non-prescription polypharmacy by frailty and sex among middle-aged and older Canadians

DA Harris, Y Guo, N Nakhla, M Tadrous… - Health …, 2022 - search.proquest.com
Background Estimates of polypharmacy have primarily been derived from prescription
claims, and less is known about the use of non-prescription medications (alone or in …

Relationship between frailty and drug use among nursing homes residents: results from the SHELTER study

ER Villani, DL Vetrano, R Liperoti, K Palmer… - Aging Clinical and …, 2021 - Springer
Abstract Background 1.5–8% of older adults live in nursing homes (NHs), presenting a high
prevalence of frailty and polypharmacy. Aims To investigate the association of frailty with …

Trends in anticoagulant use at nursing home admission and variation by frailty and chronic kidney disease among older adults with atrial fibrillation

MA Campitelli, SE Bronskill, A Huang, LC Maclagan… - Drugs & Aging, 2021 - Springer
Background Atrial fibrillation (AF) is relatively common among nursing home residents, and
decisions regarding anticoagulant therapy in this setting may be complicated by resident …

Correlates of opioid use among Ontario long-term care residents and variation by pain frequency and intensity: a cross-sectional analysis

A Iacono, MA Campitelli, SE Bronskill, DB Hogan… - Drugs & Aging, 2022 - Springer
Background Chronic non-cancer pain is common among older residents of long-term care
(LTC) homes and often poorly recognized and treated. With heightened concerns regarding …

Pharmacists' knowledge, perceptions and practices regarding frailty: a cross-sectional survey across practice settings in Canada

P Malik, N Nakhla, Y Guo, M Tadrous… - … Journal/Revue des …, 2023 - journals.sagepub.com
Background: Data on Canadian pharmacists' knowledge and perceptions about frailty in
older adults and its assessment in pharmacy practice are scarce. Methods: A cross-sectional …

'I think we could probably do more': an interview study to explore community pharmacists' experiences and perspectives of frailty and optimising medicines use in frail …

L Faulkner, CM Hughes, HE Barry - Age and Ageing, 2024 - academic.oup.com
Background Community pharmacists potentially have an important role to play in
identification of frailty and delivery of interventions to optimise medicines use for frail older …