How and when should we monitor chimerism after allogeneic stem cell transplantation?

P Bader, D Niethammer, A Willasch… - Bone marrow …, 2005 - nature.com
Chimerism analysis has become an important tool for the peri-transplant surveillance of
engraftment. It offers the possibility to realize impending graft rejection and can serve as an …

Significance of chimerism in hematopoietic stem cell transplantation: new variations on an old theme

F Khan, A Agarwal, S Agrawal - Bone marrow transplantation, 2004 - nature.com
The main goal of post-transplantation monitoring in hematopoietic stem cell transplantation
(HSCT) is to predict negative events, such as disease relapse, graft rejection and graft …

Quantitative assessment of hematopoietic chimerism after bone marrow transplantation by real-time quantitative polymerase chain reaction

M Alizadeh, M Bernard, B Danic… - Blood, The Journal …, 2002 - ashpublications.org
We have developed a real-time quantitative polymerase chain reaction (PCR) assay using
TaqMan technology (Applied Biosystems, Foster City, CA) for monitoring donor cell …

[HTML][HTML] Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells

A Omer-Javed, G Pedrazzani, L Albano, S Ghaus… - Cell, 2022 - cell.com
Hematopoietic stem/progenitor cell gene therapy (HSPC-GT) is proving successful to treat
several genetic diseases. HSPCs are mobilized, harvested, genetically corrected ex vivo …

Serial and quantitative analysis of mixed hematopoietic chimerism by PCR in patients with acute leukemias allows the prediction of relapse after allogeneic BMT

P Bader, J Beck, A Frey, PG Schlegel… - Bone marrow …, 1998 - nature.com
Within a prospective study we analyzed hematopoietic chimerism in serial peripheral blood
samples taken from 55 patients with acute leukemias (ALL 21, AML 20, MDS 14) with a …

Sequential monitoring of chimerism and detection of minimal residual disease after allogeneic blood stem cell transplantation (BSCT) using multiplex PCR …

C Thiede, M Bornhäuser, U Oelschlägel, C Brendel… - Leukemia, 2001 - nature.com
Sequential analysis of chimerism after allogeneic blood stem cell transplantation (BSCT)
has been shown to be predictive for graft failure and relapse. We have explored the impact …

Hematopoietic stem cell transplantation for homozygous β-thalassemia and β-thalassemia/hemoglobin E patients from haploidentical donors

U Anurathapan, S Hongeng, S Pakakasama… - Bone marrow …, 2016 - nature.com
Thalassemia-free survival after allogeneic stem cell transplantation (SCT) is about 80–90%
with either matched-related or-unrelated donors. We explored the use of a mismatched …

Chimerism status is a useful predictor of relapse after allogeneic stem cell transplantation for acute leukemia

M Barrios, A Jiménez-Velasco, J Román-Gómez… - …, 2003 - haematologica.org
BACKGROUND AND OBJECTIVES: The role of hematopoietic chimerism after allogeneic
stem cell transplantation (SCT) for acute leukemia remains controversial. We studied the …

Leukemia lineage-specific chimerism analysis is a sensitive predictor of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome after …

J Mattsson, M Uzunel, L Tammik, J Aschan, O Ringden - Leukemia, 2001 - nature.com
One of the major complications after allogeneic stem cell transplantation (SCT) in patients
with malignant disease is a high frequency of relapse. We have prospectively analyzed the …

Gender differences in the risk for chronic renal allograft failure

HU Meier-Kriesche, AO Ojo, SF Leavey… - …, 2001 - journals.lww.com
Background. Despite the known differences in immunological reactivity between males and
females, no differences in graft survival have been described among renal transplant …