Boolean logic in synthetic biology and biomaterials: Towards living materials in mammalian cell therapeutics

EM Bressler, S Adams, R Liu, YL Colson… - Clinical and …, 2023 - Wiley Online Library
Background: The intersection of synthetic biology and biomaterials promises to enhance
safety and efficacy in novel therapeutics. Both fields increasingly employ Boolean logic …

[HTML][HTML] An electrogenetic interface to program mammalian gene expression by direct current

J Huang, S Xue, P Buchmann, AP Teixeira… - Nature …, 2023 - nature.com
Wearable electronic devices are playing a rapidly expanding role in the acquisition of
individuals' health data for personalized medical interventions; however, wearables cannot …

Sub-1.4 cm3 capsule for detecting labile inflammatory biomarkers in situ

ME Inda-Webb, M Jimenez, Q Liu, NV Phan, J Ahn… - Nature, 2023 - nature.com
Transient molecules in the gastrointestinal tract such as nitric oxide and hydrogen sulfide
are key signals and mediators of inflammation. Owing to their highly reactive nature and …

Synthetic Gene Circuits for Regulation of Next‐Generation Cell‐Based Therapeutics

AP Teixeira, M Fussenegger - Advanced Science, 2024 - Wiley Online Library
Arming human cells with synthetic gene circuits enables to expand their capacity to execute
superior sensing and response actions, offering tremendous potential for innovative cellular …

Evolution of molecular switches for regulation of transgene expression by clinically licensed gluconate

AP Teixeira, S Xue, J Huang… - Nucleic Acids …, 2023 - academic.oup.com
Synthetic biology holds great promise to improve the safety and efficacy of future gene and
engineered cell therapies by providing new means of endogenous or exogenous control of …

[HTML][HTML] Designing transparent piezoelectric metasurfaces for adaptive optics

L Qiao, X Gao, K Ren, C Qiu, J Liu, H Jin… - Nature …, 2024 - nature.com
Simultaneously generating various motion modes with high strains in piezoelectric devices
is highly desired for high-technology fields to achieve multi-functionalities. However …

Microneedle‐Mediated Cell Therapy

Z Gao, T Sheng, W Zhang, H Feng, J Yu… - Advanced …, 2024 - Wiley Online Library
Microneedles have emerged as a promising platform for transdermal drug delivery with
prominent advantages, such as enhanced permeability, mitigated pain, and improved …

Advancing piezoelectric 2D nanomaterials for applications in drug delivery systems and therapeutic approaches

A Li, J Yang, Y He, J Wen, X Jiang - Nanoscale Horizons, 2024 - pubs.rsc.org
Precision drug delivery and multimodal synergistic therapy are crucial in treating diverse
ailments, such as cancer, tissue damage, and degenerative diseases. Electrodes that emit …

Electro-biofabrication. Coupling electrochemical and biomolecular methods to create functional bio-based hydrogels

Y Liu, E Kim, M Lei, S Wu, K Yan, J Shen… - …, 2023 - ACS Publications
Twenty years ago, this journal published a review entitled “Biofabrication with Chitosan”
based on the observations that (i) chitosan could be electrodeposited using low voltage …

Ultrasonic Electroporation for Cells Grown on Piezoelectric Film Composed of Hydroxyapatite Nanowire and PVDF

J Dolai, AR Sarkar, A Maity, B Mukherjee… - ACS Applied Materials …, 2023 - ACS Publications
The delivery of cell impermeable exogenous material into live cells by external stimuli is
critical for both biological research and therapeutic applications. Although electroporation …