Variation in DNA content has been largely ignored as a factor in evolution, particularly
following the advent of sequence-based approaches to genomic analysis. The significant …

▪ Abstract The leptotene/zygotene transition of meiosis, as defined by classical cytological
studies, is the period when homologous chromosomes, already being discernible …

Background: Structural studies of fixed cells have revealed that interphase chromosomes
are highly organized into specific arrangements in the nucleus, and have led to a picture of …

The nuclear lamina binds chromatin in vitro and is thought to function in its organization, but
genes that interact with it are unknown. Using an in vivo approach, we identified∼ 500 …

Ikaros proteins are required for normal T, B, and NK cell development and are postulated to
activate lymphocyte-specific gene expression. Here we examined Ikaros distribution in the …

Cells have evolved sophisticated multi-protein complexes that can regulate gene activity at
various steps of the transcription process. Recent advances highlight the role of nuclear …

The spatially, temporally and quantitatively correct expression of a gene requires the
presence not only of intact coding sequence, free of adverse nucleotide changes, but also …

Macrophages perform critical functions for homeostasis and immune defense in tissues
throughout the body. These innate immune cells are capable of recognizing and clearing …

A cell fraction that would today be termed “the nuclear matrix” was first described and
patented in 1948 by Russian investigators. In 1974 this fraction was rediscovered and …

During interphase in the budding yeast, Saccharomyces cerevisiae, centromeres are
clustered near one pole of the nucleus as a rosette with the spindle pole body at its hub …