Latex, a sticky emulsion produced by specialized cells called laticifers, is a crucial part of a
plant's defense system against herbivory and pathogens. It consists of a broad spectrum of …

Medicinal plants remain a valuable source for natural drug bioprospecting owing to their
multi-target spectrum. However, their use as raw materials for novel drug synthesis has been …

Strychnine is a natural product that, through isolation, structural elucidation and synthetic
efforts, shaped the field of organic chemistry. Currently, strychnine is used as a pesticide to …

The detailed metabolic map for camptothecin (CPT) biosynthesis in Camptotheca acuminata
has been proposed according to our combined omics results. However, the CYP450 …

Peyote (Lophophora williamsii) is an entheogenic and medicinal cactus native to the
Chihuahuan desert. The psychoactive and hallucinogenic properties of peyote are …

Semi-synthetic derivatives of camptothecin, a quinoline alkaloid found in the Camptotheca
acuminata tree, are potent anticancer agents. Here we discovered two C. acuminata …

Treatments with abiotic elicitors can efficiently induce the accumulation of specialized
metabolites in plants. We used a combined omics approach to analyze the elicitation effects …

The cytochrome P450 monooxygenase (CYP) superfamily comprises hemethiolate enzymes
that perform remarkable regio-and stereospecific oxidative chemistry. As such, CYPs are key …

Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a
heterocyclic moiety. These compounds display an extensive range of biological activities …

Covering: up to 2023Specialized metabolite (SM) modifications and/or decorations,
corresponding to the addition or removal of functional groups (eg hydroxyl, methyl, glycosyl …