Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …

While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS),
there is an unmet need for treatments that slow neurodegeneration resulting from secondary …

CD8+ T cells are critical mediators of cytotoxic effector function in infection, cancer and
autoimmunity. In cancer and chronic viral infection, CD8+ T cells undergo a progressive loss …

N6-methyladenosine (m6A) modification is dynamically regulated by “writer” and “eraser”
enzymes. m6A “writers” have been shown to ensure the homeostasis of CD4+ T cells, but …

Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been
suggested that in the progressive late phase, inflammatory lesion activity declines. We …

The immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis
(RA) remain poorly defined. Although increased levels of CD8+ T cells have been described …

As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …

CD8 T cell infiltration of the central nervous system (CNS) is necessary for host protection
but contributes to neuropathology. Antigen presenting cells (APCs) situated at CNS borders …