Endomembrane trafficking is essential for all eukaryotic cells. The best-characterized
membrane trafficking organelles include the endoplasmic reticulum (ER), Golgi apparatus …

The functions of coat protein complex II (COPII) coats in cargo packaging and the creation of
vesicles at the endoplasmic reticulum are conserved in eukaryotic protein secretion …

Cellular versatility depends on accurate trafficking of diverse proteins to their organellar
destinations. For the secretory pathway (followed by approximately 30% of all proteins), the …

Newly synthesized secretory proteins are exported from the endoplasmic reticulum (ER) at
specialized subcompartments called exit sites (ERES). Cargoes like procollagen are too …

Secretory proteins are transported from the endoplasmic reticulum (ER) to the Golgi complex
in carriers that are formed by the concerted activities of cytoplasmic proteins in the coat …

Sar1 is a small GTPase of the ARF family. Upon exchange of GDP for GTP, Sar1 associates
with the endoplasmic reticulum (ER) membrane and recruits COPII components …

ECM composition and architecture are tightly regulated for tissue homeostasis. Different
disorders have been associated to alterations in the levels of proteins such as collagens …

Secretory cargos are collected at endoplasmic reticulum (ER) exit sites (ERES) before
transport to the Golgi apparatus. Decades of research have provided many details of the …

Protein secretion is initiated at the endoplasmic reticulum by the COPII coat, which self-
assembles to form vesicles. Here, we examine the mechanisms by which a cargo-bound …

The endoplasmic reticulum (ER) is the main harbor for newly synthesized proteins in
eukaryotic cells. Through a continuous membrane network of sheets and tubules, the ER …