Stem‐cell‐based therapies have the potential to provide novel solutions for the treatment of
a variety of diseases, but the main obstacles to such therapies lie in the uncontrolled …

High-throughput experimental technologies often identify dozens to hundreds of genes
related to, or changed in, a biological or pathological process. From these genes one wants …

Introduction: Liver cancer is a major cause of mortality and is characterized by the
transformation of cells into an uncontrolled mass of tumor cells with many genetic and …

Generation of induced pluripotent stem cells (iPSCs) has opened new avenues for the
investigation of heart diseases, drug screening and potential autologous cardiac …

The low efficiency of reprogramming and genomic integration of virus vectors obscure the
potential application of induced pluripotent stem (iPS) cells; therefore, identification of …

Adipose-derived stem cells (ADSCs) represent a valuable source of stem cells for
regenerative medicine, but the loss of their stemness during in vitro expansion remains a …

Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-
renewal, pluripotency, and somatic cell reprogramming. However, limited information is …

Induced pluripotent stem cells (iPSCs) have the potential for creating patient-specific
regenerative medicine therapies, but the links between pluripotency and tumorigenicity raise …

In embryonic stem cells (ESCs), a core transcription factor (TF) network establishes the gene
expression program necessary for pluripotency. To address how interactions between four …

Recent studies have revealed that feed-forward loops (FFLs) as regulatory motifs have
synergistic roles in cellular systems and their disruption may cause diseases including …