[HTML][HTML] Cerebrospinal fluid cell-free tumour DNA as a liquid biopsy for primary brain tumours and central nervous system metastases

J Seoane, L De Mattos-Arruda, E Le Rhun, A Bardelli… - Annals of …, 2019 - Elsevier
Challenges in obtaining tissue specimens from patients with brain tumours limit the
diagnosis and molecular characterisation and impair the development of better therapeutic …

ctDNA-based liquid biopsy of cerebrospinal fluid in brain cancer

L Escudero, F Martínez-Ricarte, J Seoane - Cancers, 2021 - mdpi.com
Simple Summary The optimal treatment and management of patients with brain cancer
depend on the molecular characteristics of their tumour. Since the tumour changes with time …

Prognostic and predictive factors in patients with brain metastases from solid tumors: a review of published nomograms

C Nieder, MP Mehta, H Geinitz, AL Grosu - Critical reviews in oncology …, 2018 - Elsevier
Objective To review published nomograms that predict endpoints such as overall survival
(OS) or risk of intracranial relapse in patients with brain metastases from solid tumors …

Second window ICG predicts gross-total resection and progression-free survival during brain metastasis surgery

CW Teng, SS Cho, Y Singh, E De Ravin… - Journal of …, 2021 - thejns.org
OBJECTIVE Metastases are the most common intracranial malignancies and complete
resection can provide relief of neurological symptoms and reduce recurrence. The authors' …

The management of brain metastases—systematic review of neurosurgical aspects

MA Proescholdt, P Schödel, C Doenitz, T Pukrop… - Cancers, 2021 - mdpi.com
Simple Summary In this comprehensive review, we focused on the neurosurgical treatment
as an integrative part of the challenging multidisciplinary management of cerebral …

Anti-PD-(L) 1 immunotherapy for brain metastases in non-small cell lung cancer: Mechanisms, advances, and challenges

S Zhou, J Xie, Z Huang, L Deng, L Wu, J Yu, X Meng - Cancer Letters, 2021 - Elsevier
The brain is one of the most common metastatic sites in non-small cell lung cancer
(NSCLC), which is associated with an extremely poor prognosis. Despite the availability of …

The role of surgical resection in patients with brain metastases

CM Carapella, N Gorgoglione… - Current Opinion in …, 2018 - journals.lww.com
The appearance of brain metastases is considered a sign of bad prognosis. Treatment of
these lesions is important for quality of life, providing local tumour control, preventing death …

Fluorescein-guided resection of cerebral metastases is associated with greater tumor resection

MS Kofoed, CB Pedersen, MK Schulz… - Acta …, 2022 - Springer
Background Sodium fluorescein (fluorescein) crosses a disrupted blood-brain barrier
similarly to gadolinium contrast in contrast-enhancing cerebral tumors. When exposed to …

Low-intensity MR-guided focused ultrasound mediated disruption of the blood-brain barrier for intracranial metastatic diseases

Y Meng, S Suppiah, S Surendrakumar, L Bigioni… - Frontiers in …, 2018 - frontiersin.org
Low-intensity MR-guided focused ultrasound in combination with intravenously injected
microbubbles is a promising platform for drug delivery to the central nervous system past the …

LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer

R Blazquez, E Rietkötter, B Wenske… - … journal of cancer, 2020 - Wiley Online Library
More than half of all brain metastases show infiltrating rather than displacing growth at the
macro‐metastasis/organ parenchyma interface (MMPI), a finding associated with shorter …