In the past few decades, drug metabolism research has played an ever increasing role in the
design of drugs. 1− 3 In vitro metabolism assays 4 have become an integral part of the …

Thrombosis is the underlying cause of a host of common, debilitating, and often fatal
cardiovascular disorders. Formation of thrombi in the arterial circulation can lead to acute …

Anticoagulant drugs comprise a specific subcategory of antithrombotic agents that act to
inhibit blood coagulation at various stages, reducing clot development and ultimately …

Preclinical drug metabolism studies play a key role in the lead identification and optimization
process in drug discovery. Characterization of the metabolic pathways of new chemical …

Chiral β-hydroxy sulfones are important building blocks and can be found in many bioactive
compounds and pharmaceuticals. In this work, we realized the first example of manganese …

In recent years, large-scale structure-based virtual screening has attracted increasing levels
of interest for identification of novel compounds corresponding to potential drug targets. It is …

Background The process of drug development and discovery is costly and slow. Although an
understanding of molecular design principles and biochemical processes has progressed, it …

A regioselective intramolecular cyclization/halogenation reaction of N-alkoxy-o-
alkynylbenzamides with CuCl2/NCS was developed. The corresponding 3 …

Pattern recognition receptors (PRRs) are evolutionarily ancient and crucial components of
innate immunity, recognizing danger-associated molecular patterns (DAMPs) and activating …

To prevent thromboses after surgery, patients have until now had to inject themselves daily
with heparin. For stroke prophylaxis in atrial fibrillation, patients take vitamin K antagonists of …