Rates of individuals struggling with psychostimulant use disorder (PSUD), defined as
chronic use of psychostimulants despite negative consequences, are growing rapidly over …

Chronic stress is a major risk factor for depression onset. However, it remains unclear how
repeated stress sculpts neural circuits and finally elicits depression. Given the essential role …

Women are more sensitive to cocaine craving elicited by stimuli associated with relapse.
Ovarian hormones modulate cocaine craving and may therefore function as risk factors or …

Background Depression is the most common mental illness. Mounting evidence suggests
that dysregulation of extracellular ATP (adenosine triphosphate) is involved in the …

Despite significant advancements in our understanding of addiction at the neurobiological
level, a highly effective extinction procedure for preventing relapse remains elusive. In this …

Mapping the connectivity of diverse neuronal types provides the foundation for
understanding the structure and function of neural circuits. High-throughput and low-cost …

To understand how the brain produces behavior, we must elucidate the relationships
between neuronal connectivity and function. The medial prefrontal cortex (mPFC) is critical …

The medial prefrontal cortex (mPFC) sends projections to numerous brain regions and is
believed to play a significant role in depression and anxiety. One of the key downstream …

Psychostimulant exposure alters the activity of ventral pallidum (VP) projection neurons.
However, the molecular underpinnings of these circuit dysfunctions are unclear. We used …

Neurons in the cortex are heterogenous, sending diverse axonal projections to multiple
brain regions. Unraveling the logic of these projections requires single-neuron resolution …