The tubulin code and its role in controlling microtubule properties and functions
C Janke, MM Magiera - Nature Reviews Molecular Cell Biology, 2020 - nature.com
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …
Structural biology of cilia and intraflagellar transport
Cilia are ubiquitous microtubule-based eukaryotic organelles that project from the cell to
generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal …
generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal …
Genes and molecular pathways underpinning ciliopathies
Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …
Microtubules and microtubule-associated proteins
HV Goodson, EM Jonasson - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Microtubules act as “railways” for motor-driven intracellular transport, interact with accessory
proteins to assemble into larger structures such as the mitotic spindle, and provide an …
proteins to assemble into larger structures such as the mitotic spindle, and provide an …
Emerging mechanistic understanding of cilia function in cellular signalling
Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …
participate broadly in human health, physiology and disease. Cilia generate a unique …
Seriously cilia: A tiny organelle illuminates evolution, disease, and intercellular communication
C Derderian, GI Canales, JF Reiter - Developmental cell, 2023 - cell.com
The borders between cell and developmental biology, which have always been permeable,
have largely dissolved. One manifestation is the blossoming of cilia biology, with cell and …
have largely dissolved. One manifestation is the blossoming of cilia biology, with cell and …
Mechanism and regulation of centriole and cilium biogenesis
DK Breslow, AJ Holland - Annual review of biochemistry, 2019 - annualreviews.org
The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …
symmetry. Centrioles form the core of centrosomes, which organize the interphase …
Cilia dysfunction in lung disease
AE Tilley, MS Walters, R Shaykhiev… - Annual review of …, 2015 - annualreviews.org
A characteristic feature of the human airway epithelium is the presence of ciliated cells
bearing motile cilia, specialized cell surface projections containing axonemes composed of …
bearing motile cilia, specialized cell surface projections containing axonemes composed of …
The centrosome cycle: centriole biogenesis, duplication and inherent asymmetries
Centrosomes are microtubule-organizing centres of animal cells. They influence the
morphology of the microtubule cytoskeleton, function as the base for the primary cilium and …
morphology of the microtubule cytoskeleton, function as the base for the primary cilium and …
The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization
Both the basal body and the microtubule‐based axoneme it nucleates have evolutionarily
conserved subdomains crucial for cilium biogenesis, function and maintenance. Here, we …
conserved subdomains crucial for cilium biogenesis, function and maintenance. Here, we …