In tumourigenesis, oncogenes or dysregulated tumour suppressor genes alter the canonical
translation machinery leading to a reprogramming of the translatome that, in turn, promotes …

The dysregulation of mRNA translation is common in malignancies and may lead to
tumorigenesis and progression. Eukaryotic initiation factor 4A (eIF4A) proteins are essential …

The liver is a metabolic hub characterized by high levels of protein synthesis. Eukaryotic
initiation factors, eIFs, control the first phase of translation, initiation. Initiation factors are …

Background Hepatocellular carcinoma (HCC) remains one of the most common cancers
worldwide and tends to be detected at an advanced stage. More effective biomarkers for …

methylcytosine (m5C) is a post-transcriptional RNA modification identified, m5C readers can
specifically identify and bind to m5C. ALYREF and YBX1 as members of m5C readers that …

Purpose Sepsis-induced acute lung injury is related to high mortality. MiR-2113 possesses
important functions in human diseases. This research aimed to clarify the role and …

Dysregulated protein synthesis is a hallmark of tumors. mRNA translation reprogramming
contributes to tumorigenesis, which is fueled by abnormalities in ribosome formation, tRNA …

Purpose. Congenital hydrocephalus is one of the most common birth defects worldwide.
Exosomal microRNAs (miRNAs) in body fluids have been implicated in many diseases …

A growing number of dysregulated long non‑coding (lnc) RNAs have been verified to serve
an essential role in human prostate cancer. However, the underlying mechanisms of lncRNA …

Objective: Hepatocellular carcinoma (HCC) is considered the highest recorded malignancy
in Egypt. The shortage of appropriate biomarkers for early detection often results in the late …