Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Various preclinical models have been developed to clarify the pathophysiology of prostate
cancer (PCa). Traditional PCa cell lines from clinical metastatic lesions, as exemplified by …

Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and
represents the major therapeutic target for treating metastatic prostate cancer (mPC) …

New incidence of prostate cancer is a major public health issue in the Western world, and
has been rising in other areas of the globe in recent years. In an effort to understanding the …

Purpose: Prostate cancer translational research has been hampered by the lack of
comprehensive and tractable models that represent the genomic landscape of clinical …

US9572874B2 - Composition comprising a complexed (M)RNA and a naked mRNA for
providing or enhancing an immunostimulatory response in a mammal and uses thereof - Google …

Most oncology compounds entering clinical development have passed stringent preclinical
pharmacology evaluation criteria. However, only a small fraction of experimental agents …

Genome-wide association studies (GWAS) have revolutionized the field of cancer genetics,
but the causal links between increased genetic risk and onset/progression of disease …

Background Prostate cancer is a broad-spectrum disease, spanning from indolent to a
highly aggressive lethal malignancy. Prostate cancer cell lines are essential tools to …

The transgenic adenocarcinoma of mouse prostate (TRAMP) model is widely used in
prostate cancer research because of rapid tumor onset and progression. The transgenic …