Molecular genetics of prostate cancer: new prospects for old challenges
MM Shen, C Abate-Shen - Genes & development, 2010 - genesdev.cshlp.org
Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …
cancer-related mortality and morbidity in men. Since early studies on the role of the …
Application of prostate cancer models for preclinical study: advantages and limitations of cell lines, patient-derived xenografts, and three-dimensional culture of patient …
T Namekawa, K Ikeda, K Horie-Inoue, S Inoue - Cells, 2019 - mdpi.com
Various preclinical models have been developed to clarify the pathophysiology of prostate
cancer (PCa). Traditional PCa cell lines from clinical metastatic lesions, as exemplified by …
cancer (PCa). Traditional PCa cell lines from clinical metastatic lesions, as exemplified by …
[HTML][HTML] Androgen receptor pathway-independent prostate cancer is sustained through FGF signaling
EG Bluemn, IM Coleman, JM Lucas, RT Coleman… - Cancer cell, 2017 - cell.com
Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and
represents the major therapeutic target for treating metastatic prostate cancer (mPC) …
represents the major therapeutic target for treating metastatic prostate cancer (mPC) …
[HTML][HTML] In vitro and in vivo model systems used in prostate cancer research
D Cunningham, Z You - Journal of biological methods, 2015 - ncbi.nlm.nih.gov
New incidence of prostate cancer is a major public health issue in the Western world, and
has been rising in other areas of the globe in recent years. In an effort to understanding the …
has been rising in other areas of the globe in recent years. In an effort to understanding the …
A PDX/organoid biobank of advanced prostate cancers captures genomic and phenotypic heterogeneity for disease modeling and therapeutic screening
ML Beshiri, CM Tice, C Tran, HM Nguyen… - Clinical Cancer …, 2018 - AACR
Purpose: Prostate cancer translational research has been hampered by the lack of
comprehensive and tractable models that represent the genomic landscape of clinical …
comprehensive and tractable models that represent the genomic landscape of clinical …
Composition comprising a complexed (M) RNA and a naked MRNA for providing or enhancing an immunostimulatory response in a mammal and uses thereof
M Fotin-Mleczek, S Voss - US Patent 9,572,874, 2017 - Google Patents
US9572874B2 - Composition comprising a complexed (M)RNA and a naked mRNA for
providing or enhancing an immunostimulatory response in a mammal and uses thereof - Google …
providing or enhancing an immunostimulatory response in a mammal and uses thereof - Google …
Advances in patient-derived tumor xenografts: from target identification to predicting clinical response rates in oncology
E Rosfjord, J Lucas, G Li, HP Gerber - Biochemical pharmacology, 2014 - Elsevier
Most oncology compounds entering clinical development have passed stringent preclinical
pharmacology evaluation criteria. However, only a small fraction of experimental agents …
pharmacology evaluation criteria. However, only a small fraction of experimental agents …
Comprehensive functional annotation of 77 prostate cancer risk loci
DJ Hazelett, SK Rhie, M Gaddis, C Yan… - PLoS …, 2014 - journals.plos.org
Genome-wide association studies (GWAS) have revolutionized the field of cancer genetics,
but the causal links between increased genetic risk and onset/progression of disease …
but the causal links between increased genetic risk and onset/progression of disease …
Characterisation of cell lines derived from prostate cancer patients with localised disease
L Moya, C Walpole, F Rae, S Srinivasan… - Prostate Cancer and …, 2023 - nature.com
Background Prostate cancer is a broad-spectrum disease, spanning from indolent to a
highly aggressive lethal malignancy. Prostate cancer cell lines are essential tools to …
highly aggressive lethal malignancy. Prostate cancer cell lines are essential tools to …
Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer
T Chiaverotti, SS Couto, A Donjacour, JH Mao… - The American journal of …, 2008 - Elsevier
The transgenic adenocarcinoma of mouse prostate (TRAMP) model is widely used in
prostate cancer research because of rapid tumor onset and progression. The transgenic …
prostate cancer research because of rapid tumor onset and progression. The transgenic …