Canine prostate adenocarcinoma (PAC) and transitional cell carcinoma (TCC) of prostate
and urinary bladder are highly invasive and metastatic tumors of closely neighbored organs …

Somatostatin (SST), cortistatin (CORT), and their receptors (SSTR1-5/sst5TMD4-TMD5)
comprise a multifactorial hormonal system involved in the regulation of numerous …

Identification of the genes involved in prostate cancer (PCa) progression to a virulent and
androgen-independent (AI) form is a major focus in the field. cDNA microarray was used to …

Cyclin D1b is a splice variant of the cell cycle regulator cyclin D1 and is known to harbor
divergent and highly oncogenic functions in human cancer. While cyclin D1b is induced …

Patient-derived xenografts (PDXs) are generated by engrafting human tumours into mice.
Serially transplantable PDXs are used to study tumour biology and test therapeutics, linking …

To uncover the mechanism by which human prostate cancer progresses, we performed a
genetic screen for regulators of human prostate cancer progression using the Drosophila …

Aim: To develop new therapies for prostate cancer, disease heterogeneity must be
addressed. This includes patient variation, multi-focal disease, cellular heterogeneity …

Despite considerable success in treatment of early stage localized prostate cancer (PC),
acute inadequacy of late stage PC treatment and its inherent heterogeneity poses a …

An enzyme-responsive peptide drug conjugate was developed for TGX-D1, a promising
PI3K inhibitor for prostate cancer therapy. LNCaP-specific KYL peptide was used as the …

Abstract Background Prostate cancer (PCa) models in mice and rats are limited by their size
and lack of a clearly delineated or easily accessible prostate gland. The canine PCa model …