Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

Serotonin has been implicated in the control of satiety for almost four decades. Historically,
the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has …

The amygdala is a limbic brain region that plays a key role in emotional processing,
neuropsychiatric disorders, and the emotional‐affective dimension of pain. Preclinical and …

Symptoms of cognitive dysfunction like memory loss, poor concentration, impaired learning
and executive functions are characteristic features of both schizophrenia and Alzheimer's …

Serotonin regulates many physiological processes including sleep, appetite, and mood.
Thus, serotonergic system is an important target in the treatment of psychiatric disorders …

Two primary animal models persist for assessing hallucinogenic potential of novel
compounds and for examining the pharmacological and neurobiological substrates …

Ketamine, an NMDA receptor antagonist has been shown to induce aberrant behaviour
phenotypes in rodents, some of which are known to simulate the behaviour abnormalities …

Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …

Background: Symptoms of cognitive impairment such as poor concentration, memory loss
and difficulty with decision making are prevalent in patients with depression, but currently …

Dementia represents a global health challenge due to the increase in elderly population
worldwide. In addition to memory loss, dementia often results in severe behavioral and …