Drug discovery targeting human 5-HT2C receptors: Residues S3. 36 and Y7. 43 impact ligand—Binding pocket structure via hydrogen bond formation
CE Canal, TC Cordova-Sintjago, NY Villa… - European journal of …, 2011 - Elsevier
Specific activation of serotonin (5-HT) 5-HT2C G protein-coupled receptors may be
therapeutic for obesity and neuropsychiatric disorders. Mutagenesis coupled with …
therapeutic for obesity and neuropsychiatric disorders. Mutagenesis coupled with …
Agomelatine modulates calcium signaling through protein kinase C and phospholipase C‐mediated mechanisms in rat sensory neurons
Agomelatine, a novel antidepressant exerting its effects through melatonergic and
serotonergic systems, implicated to be effective against pain including neuropathic pain but …
serotonergic systems, implicated to be effective against pain including neuropathic pain but …
Insights into the influence of 5-HT2c aminoacidic variants with the inhibitory action of serotonin inverse agonists and antagonists
R Galeazzi, L Massaccesi, F Piva, G Principato… - Journal of molecular …, 2014 - Springer
Specific modulation of serotonin 5-HT 2C G protein-coupled receptors may be therapeutic
for obesity and neuropsychiatric disorders. The different efficacy of drugs targeting these …
for obesity and neuropsychiatric disorders. The different efficacy of drugs targeting these …
Cross-species translational findings in the discriminative stimulus effects of ethanol
The progress on understanding the pharmacological basis of ethanol's discriminative
stimulus effects has been substantial, but appears to have plateaued in the past decade …
stimulus effects has been substantial, but appears to have plateaued in the past decade …
Aromatic interactions impact ligand binding and function at serotonin 5-HT2C G protein-coupled receptors: receptor homology modelling, ligand docking, and …
T Córdova-Sintjago, N Villa, L Fang, RG Booth - Molecular physics, 2014 - Taylor & Francis
The serotonin (5-hydroxytryptamine, 5-HT) 5-HT2 G protein-coupled receptor (GPCR) family
consists of types 2A, 2B, and 2C that share∼ 75% transmembrane (TM) sequence identity …
consists of types 2A, 2B, and 2C that share∼ 75% transmembrane (TM) sequence identity …
Serotonin Receptors of 5-HT2 Type in the Hypothalamic Arcuate Nuclei Positively Regulate Liver Cytochrome P450 via Stimulation of the Growth Hormone–Releasing …
E Bromek, M Rysz, A Haduch, WA Daniel - Drug Metabolism and …, 2019 - ASPET
Our recent study carried out after local injection of the serotonergic neurotoxin 5, 7-
dihydroxytryptamine into the arcuate nucleus (ARC) of the hypothalamus suggested a …
dihydroxytryptamine into the arcuate nucleus (ARC) of the hypothalamus suggested a …
Synthesis and Evaluation of Pyridyloxypyridyl Indole Carboxamides as Potential PET Imaging Agents for 5-HT2C Receptors
F Zeng, JA Nye, RJ Voll, L Howell… - ACS Medicinal …, 2018 - ACS Publications
Nine pyridyloxypyridyl indole carboxamides were synthesized and displayed high affinities
for 5-HT2C receptors and high selectivity over 5-HT2A and 5-HT2B. Among them, 6-methyl …
for 5-HT2C receptors and high selectivity over 5-HT2A and 5-HT2B. Among them, 6-methyl …
[HTML][HTML] Urocortin1-induced anorexia is regulated by activation of the serotonin 2C receptor in the brain
Y Harada, K Takayama, S Ro, M Ochiai, M Noguchi… - Peptides, 2014 - Elsevier
This study was conducted to determine the mechanisms by which serotonin (5-
hydroxytryptamine, 5-HT) receptors are involved in the suppression of food intake in a rat …
hydroxytryptamine, 5-HT) receptors are involved in the suppression of food intake in a rat …
Complex role of the serotonin receptors in depression: Implications for treatment
Evidence from pharmacological, neuroimaging, postmortem, and genetic studies underlines
the various roles of 5-HT receptor subtypes in the pathogenesis of major depressive …
the various roles of 5-HT receptor subtypes in the pathogenesis of major depressive …
Human serotonin 5‐HT2C G protein‐coupled receptor homology model from the β2 adrenoceptor structure: Ligand docking and mutagenesis studies
T Córdova‐Sintjago, N Villa, C Canal… - International journal of …, 2012 - Wiley Online Library
Activation of the serotonin (5‐hydroxytryptamine, 5‐HT) 5HT2C G protein‐coupled receptor
(GPCR) is proposed as novel pharmacotherapy for obesity and neuropsychiatric disorders …
(GPCR) is proposed as novel pharmacotherapy for obesity and neuropsychiatric disorders …