There is a wealth of new fluorescent reporter technologies for tagging of many cellular and
subcellular processes in vivo. This imposed contrast is now captured with an increasing …

Three major analytical tools in imaging science are summarized and demonstrated relative
to optical imaging in vivo. Standard resolution testing is optimal when infinite contrast is …

Bioluminescence tomography (BLT) is used to localize and quantify bioluminescent sources
in a small living animal. By advancing bioluminescent imaging to a tomographic framework …

We present a novel fluorescence imaging system developed for real-time interventional
imaging applications. The system implements a correction scheme that improves the …

Optogenetic defibrillation of hearts expressing light-sensitive cation channels (eg, ChR2)
has been proposed as an alternative to conventional electrotherapy. Past modeling work …

Measurement of tissue optical absorption and (transport) reduced scattering coefficients
(μ_a and μ_s', respectively) is fundamental to many applications of light in medicine and …

Volumetric detection and accurate quantification of fluorescent proteins in entire animals
would greatly enhance our ability to monitor biological processes in vivo. Here we present a …

Microscopy of fluorescent proteins has enabled unprecedented insights into visualizing
gene expression in living systems. Imaging deeper into animals, however, has been limited …

The main idea behind this book is to present a rigorous derivation of the equations that
govern light propagation in highly scattering media, with an emphasis on their applications …

Delivering accurate information through thick biological tissues is critical in many biomedical
applications. However, it is challenging to realize accurate optical information transmission …