The war against bacteria, from the past to present and beyond

L Bottalico, IA Charitos, MA Potenza… - Expert Review of Anti …, 2022 - Taylor & Francis
Introduction The human defense against microorganisms dates back to the ancient
civilizations, with attempts to use substances from vegetal, animal, or inorganic origin to fight …

Anthranilate acts as a signal to modulate biofilm formation, virulence, and antibiotic tolerance of Pseudomonas aeruginosa and surrounding bacteria

HJ Hwang, XH Li, SK Kim, JH Lee - Microbiology spectrum, 2022 - Am Soc Microbiol
Anthranilate is a diffusible molecule produced by Pseudomonas aeruginosa and
accumulates as P. aeruginosa grows. Anthranilate is an important intermediate for the …

[HTML][HTML] Synergy between Human Peptide LL-37 and Polymyxin B against Planktonic and Biofilm Cells of Escherichia coli and Pseudomonas aeruginosa

KE Ridyard, M Elsawy, D Mattrasingh, D Klein… - Antibiotics, 2023 - mdpi.com
The rise in antimicrobial resistant bacteria is limiting the number of effective treatments for
bacterial infections. Escherichia coli and Pseudomonas aeruginosa are two of the …

Unlocking the bacterial membrane as a therapeutic target for next-generation antimicrobial amphiphiles

D Mehta, V Saini, B Aggarwal, A Khan… - Molecular Aspects of …, 2021 - Elsevier
Gram-positive bacteria like Enterococcus faecium and Staphylococcus aureus, and Gram-
negative bacteria like Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …

[HTML][HTML] Antibiotic Resistance and Phylogeny of Pseudomonas spp. Isolated over Three Decades from Chicken Meat in the Norwegian Food Chain

E Heir, B Moen, AW Åsli, M Sunde, S Langsrud - Microorganisms, 2021 - mdpi.com
Pseudomonas is ubiquitous in nature and a predominant genus in many foods and food
processing environments, where it primarily represents major food spoilage organisms. The …

Prevalence and clinical consequences of colistin heteroresistance and evolution into full resistance in carbapenem-resistant Acinetobacter baumannii

H Kon, A Hameir, A Nutman, E Temkin… - Microbiology …, 2023 - Am Soc Microbiol
Colistin heteroresistance (HR) refers to a bacterial population comprised of several
subpopulations with different levels of resistance to colistin. In this study, we discuss the …

[HTML][HTML] Adverse drug reactions relevant to drug resistance and ineffectiveness associated with meropenem, linezolid, and colistin: an analysis based on spontaneous …

BI Vintila, AM Arseniu, A Butuca, M Sava, V Bîrluțiu… - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance is considered one of the major threats to public health and is an
important factor that influences the patient's outcome in the intensive care unit …

[HTML][HTML] Enhanced antimicrobial and antibiofilm effect of new colistin-loaded human albumin nanoparticles

S Scutera, M Argenziano, R Sparti, F Bessone… - Antibiotics, 2021 - mdpi.com
Multidrug-resistant (MDR) Gram-negative bacteria (GNB), such as Acinetobacter and
Klebsiella, are responsible for severe hospital-acquired infections. Colistin, despite its …

A molecular overview of the polymyxin-LPS interaction in the context of its mode of action and resistance development

I Padhy, SK Dwibedy, SS Mohapatra - Microbiological Research, 2024 - Elsevier
With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of
novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action …

[HTML][HTML] A Real-World Study on the Clinical Characteristics, Outcomes, and Relationship between Antibiotic Exposure and Clostridioides difficile Infection

BI Vintila, AM Arseniu, C Morgovan, A Butuca… - Antibiotics, 2024 - mdpi.com
Clostridioides difficile is a Gram-positive bacteria that causes nosocomial infections,
significantly impacting public health. In the present study, we aimed to describe the clinical …