One Health or Three? Transmission modelling of Klebsiella isolates reveals ecological barriers to transmission between humans, animals and the environment

H Thorpe, R Booton, T Kallonen, MJ Gibbon, N Couto… - BioRxiv, 2021 - biorxiv.org
The Klebsiella group is highly diverse both genetically and ecologically, being commonly
recovered from humans, livestock, plants, soil, water, and wild animals. Many species are …

Antibiotic cross-linked micelles with reduced toxicity for multidrug-resistant bacterial sepsis treatment

X Yang, H Ren, H Zhang, G Liu, Z Jiang… - … Applied Materials & …, 2021 - ACS Publications
One potential approach to address the rising threat of antibiotic resistance is through novel
formulations of established drugs. We designed antibiotic cross-linked micelles (ABC …

The role of bacterial transport systems in the removal of host antimicrobial peptides in Gram-negative bacteria

JMA Blair, K Zeth, VN Bavro… - FEMS microbiology …, 2022 - academic.oup.com
Antibiotic resistance is a global issue that threatens our progress in healthcare and life
expectancy. In recent years, antimicrobial peptides (AMPs) have been considered as …

[HTML][HTML] Genomic traits of multidrug resistant enterotoxigenic Escherichia coli isolates from diarrheic pigs

J Hu, J Li, X Huang, J Xia, M Cui, Y Huang… - Frontiers in …, 2023 - frontiersin.org
Diarrhea caused by enterotoxigenic Escherichia coli (ETEC) infections poses a significant
challenge in global pig farming. To address this issue, the study was conducted to identify …

Enhanced synergistic antibacterial and antibiofilm efficacy of main-chain polysulfoniums with antibiotics by balancing charge density and amphiphilicity

Y Zhao, X Wang, Y Hu, J Zhao, M Sun… - ACS Applied Polymer …, 2023 - ACS Publications
Infection diseases caused by Gram-negative pathogens are exceedingly difficult to treat
because their characteristic outer membrane limits antibiotic entry. Herein, we report the …

[HTML][HTML] Drug repurposing approaches towards defeating multidrug-resistant gram-negative pathogens: Novel polymyxin/non-antibiotic combinations

A Koh Jing Jie, M Hussein, GG Rao, J Li, T Velkov - Pathogens, 2022 - mdpi.com
Multidrug-resistant (MDR) Gram-negative pathogens remain an unmet public health threat.
In recent times, increased rates of resistance have been reported not only to commonly used …

Colistin enhances rifampicin's antimicrobial action in colistin-resistant pseudomonas aeruginosa biofilms

E Armengol, KN Kragh, T Tolker-Nielsen… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
The emergence of multidrug-resistant Pseudomonas aeruginosa infections has urged the
need to find new strategies, such as the use of combinations of antibiotics. Among these, the …

[HTML][HTML] Antimicrobial Resistance Profiles and Co-Existence of Multiple Antimicrobial Resistance Genes in mcr-Harbouring Colistin-Resistant Enterobacteriaceae …

MR Karim, Z Zakaria, L Hassan, N Mohd Faiz… - Antibiotics, 2023 - mdpi.com
The co-existence of the colistin resistance (mcr) gene with multiple drug-resistance genes
has raised concerns about the possibility of the development of pan-drug-resistant bacteria …

Structure, Function, and Physicochemical Properties of Pore-forming Antimicrobial Peptides

NH Goki, ZA Tehranizadeh, MR Saberi… - Current …, 2024 - ingentaconnect.com
Antimicrobial peptides (AMPs), a class of antimicrobial agents, possess considerable
potential to treat various microbial ailments. The broad range of activity and rare complete …

[HTML][HTML] Macrocycle-antibiotic hybrids: A path to clinical candidates

AS Surur, D Sun - Frontiers in Chemistry, 2021 - frontiersin.org
The tale of abate in antibiotics continued defense mechanisms that chaperone the rise of
drug-defying superbugs—on the other hand, the astray in antibacterial drug discovery and …