One Health or Three? Transmission modelling of Klebsiella isolates reveals ecological barriers to transmission between humans, animals and the environment
The Klebsiella group is highly diverse both genetically and ecologically, being commonly
recovered from humans, livestock, plants, soil, water, and wild animals. Many species are …
recovered from humans, livestock, plants, soil, water, and wild animals. Many species are …
Antibiotic cross-linked micelles with reduced toxicity for multidrug-resistant bacterial sepsis treatment
X Yang, H Ren, H Zhang, G Liu, Z Jiang… - … Applied Materials & …, 2021 - ACS Publications
One potential approach to address the rising threat of antibiotic resistance is through novel
formulations of established drugs. We designed antibiotic cross-linked micelles (ABC …
formulations of established drugs. We designed antibiotic cross-linked micelles (ABC …
The role of bacterial transport systems in the removal of host antimicrobial peptides in Gram-negative bacteria
Antibiotic resistance is a global issue that threatens our progress in healthcare and life
expectancy. In recent years, antimicrobial peptides (AMPs) have been considered as …
expectancy. In recent years, antimicrobial peptides (AMPs) have been considered as …
[HTML][HTML] Genomic traits of multidrug resistant enterotoxigenic Escherichia coli isolates from diarrheic pigs
J Hu, J Li, X Huang, J Xia, M Cui, Y Huang… - Frontiers in …, 2023 - frontiersin.org
Diarrhea caused by enterotoxigenic Escherichia coli (ETEC) infections poses a significant
challenge in global pig farming. To address this issue, the study was conducted to identify …
challenge in global pig farming. To address this issue, the study was conducted to identify …
Enhanced synergistic antibacterial and antibiofilm efficacy of main-chain polysulfoniums with antibiotics by balancing charge density and amphiphilicity
Y Zhao, X Wang, Y Hu, J Zhao, M Sun… - ACS Applied Polymer …, 2023 - ACS Publications
Infection diseases caused by Gram-negative pathogens are exceedingly difficult to treat
because their characteristic outer membrane limits antibiotic entry. Herein, we report the …
because their characteristic outer membrane limits antibiotic entry. Herein, we report the …
[HTML][HTML] Drug repurposing approaches towards defeating multidrug-resistant gram-negative pathogens: Novel polymyxin/non-antibiotic combinations
Multidrug-resistant (MDR) Gram-negative pathogens remain an unmet public health threat.
In recent times, increased rates of resistance have been reported not only to commonly used …
In recent times, increased rates of resistance have been reported not only to commonly used …
Colistin enhances rifampicin's antimicrobial action in colistin-resistant pseudomonas aeruginosa biofilms
E Armengol, KN Kragh, T Tolker-Nielsen… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
The emergence of multidrug-resistant Pseudomonas aeruginosa infections has urged the
need to find new strategies, such as the use of combinations of antibiotics. Among these, the …
need to find new strategies, such as the use of combinations of antibiotics. Among these, the …
[HTML][HTML] Antimicrobial Resistance Profiles and Co-Existence of Multiple Antimicrobial Resistance Genes in mcr-Harbouring Colistin-Resistant Enterobacteriaceae …
The co-existence of the colistin resistance (mcr) gene with multiple drug-resistance genes
has raised concerns about the possibility of the development of pan-drug-resistant bacteria …
has raised concerns about the possibility of the development of pan-drug-resistant bacteria …
Structure, Function, and Physicochemical Properties of Pore-forming Antimicrobial Peptides
NH Goki, ZA Tehranizadeh, MR Saberi… - Current …, 2024 - ingentaconnect.com
Antimicrobial peptides (AMPs), a class of antimicrobial agents, possess considerable
potential to treat various microbial ailments. The broad range of activity and rare complete …
potential to treat various microbial ailments. The broad range of activity and rare complete …
[HTML][HTML] Macrocycle-antibiotic hybrids: A path to clinical candidates
AS Surur, D Sun - Frontiers in Chemistry, 2021 - frontiersin.org
The tale of abate in antibiotics continued defense mechanisms that chaperone the rise of
drug-defying superbugs—on the other hand, the astray in antibacterial drug discovery and …
drug-defying superbugs—on the other hand, the astray in antibacterial drug discovery and …