Recent progress in the science of aging is driven largely by the use of model systems,
ranging from yeast and nematodes to mice. These models have revealed conservation in …

Oxidatively generated damage to DNA has been implicated in the pathogenesis of a wide
variety of diseases. Increasingly, interest is also focusing upon the effects of damage to the …

Chronic exposure of pancreatic islets to supraphysiologic concentrations of glucose causes
adverse alterations in β cell function, a phenomenon termed glucose toxicity and one that …

First Published July 12, 2001; 10.1152/ajprenal. 0071.2001.—Generation of reactive oxygen
species and nitric oxide in hypoxia-reperfusion injury may form a cytotoxic metabolite …

Achondroplasia is the most common genetic form of human dwarfism, for which there is
presently no effective therapy. C-type natriuretic peptide (CNP) is a newly identified …

We evaluated the effects of chronic hyperglycemia on L5 dorsal root ganglion (DRG)
neurons using immunohistochemical and electrophysiologic techniques for evidence of …

Oxidative stress is reputed to be a significant contributor to the aging process and a key
factor affecting species longevity. The tremendous natural variation in maximum species …

Purpose: Endometriotic cysts are known to transform into ovarian cancers, such as clear cell
and endometrioid carcinomas. We hypothesized that an iron-rich environment produced by …

The earliest work on oxidation of a biologically important protein was on the effects of
selected radicals generated by radiolysis on the enzyme, lysozyme (Adams et al., 1969) …

Hyperglycemia causes the autoxidation of glucose, glycation of proteins, and the activation
of polyol metabolism. These changes accelerate generation of reactive oxygen species …