Mitochondria: It is all about energy

A Casanova, A Wevers, S Navarro-Ledesma… - Frontiers in …, 2023 - frontiersin.org
Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

Inhaled toxicants and pulmonary lipid metabolism: biological consequences and therapeutic interventions

HB Lovins, BE Bathon, SR Shaikh… - Toxicological …, 2023 - academic.oup.com
Inhaled toxicants drive the onset of and exacerbate preexisting chronic pulmonary diseases,
however, the biological mechanisms by which this occurs are largely unknown. Exposure to …

Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients

J Diray-Arce, S Fourati, ND Jayavelu, R Patel… - Cell Reports …, 2023 - cell.com
The IMPACC cohort, composed of> 1,000 hospitalized COVID-19 participants, contains five
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1 …

Fine particulate matter contributes to COPD-like pathophysiology: experimental evidence from rats exposed to diesel exhaust particles

Z Fang, Z Wang, Z Chen, Y Peng, Y Fu, Y Yang… - Respiratory …, 2024 - Springer
Background Ambient fine particulate matter (PM2. 5) is considered a plausible contributor to
the onset of chronic obstructive pulmonary disease (COPD). Mechanistic studies are needed …

Role of different mechanisms in pro-inflammatory responses triggered by traffic-derived particulate matter in human bronchiolar epithelial cells

M Refsnes, T Skuland, R Jørgensen… - Particle and Fibre …, 2023 - Springer
Background Traffic-derived particles are important contributors to the adverse health effects
of ambient particulate matter (PM). In Nordic countries, mineral particles from road pavement …

The effect of multiple factors on water-soluble inorganic ions in diesel particulate matter emissions

M Fu, T Jin, L Qu, S Liu, K Lu, Y Tao, S Zhao… - Journal of Hazardous …, 2023 - Elsevier
The water-soluble inorganic ions (WSII) in diesel particulate matter (DPM) have a significant
impact on ambient air quality and human health. In this study, the 12 groups of bench tests …

Integrated transcriptomics and lipidomics investigation of the mechanism underlying the gastrointestinal mucosa damage of Loropetalum chinense (R. Br.) and its …

J Song, Z Jiang, X Wei, Y Zhang, B Bian, H Wang… - Phytomedicine, 2023 - Elsevier
Abstract Background Loropetalum chinensis (R. Br) Oliv (Bhjm), a Chinese folk herbal
medicine, was traditionally used in the treatment of wound bleeding and skin ulcers. A new …

Liquid application dosing alters the physiology of air-liquid interface (ALI) primary human bronchial epithelial cell/lung fibroblast co-cultures and in vitro testing …

NM Mallek, EM Martin, LA Dailey… - Frontiers in …, 2024 - frontiersin.org
Differentiated primary human bronchial epithelial cell (dpHBEC) cultures grown under air-
liquid interface (ALI) conditions exhibit key features of the human respiratory tract and are …

Occupational quartz and particle exposure affect systemic levels of inflammatory markers related to inflammasome activation and cardiovascular disease

A Hedbrant, C Engström, L Andersson, D Eklund… - Environmental …, 2023 - Springer
Background The inflammatory responses are central components of diseases associated
with particulate matter (PM) exposure, including systemic diseases such as cardiovascular …

[HTML][HTML] Defining the in vivo mechanism of air pollutant toxicity using murine stress response biomarkers

F Inesta-Vaquera, L Miyashita, J Grigg… - Science of the Total …, 2023 - Elsevier
Air pollution can cause a wide range of serious human diseases. For the informed
instigation of interventions which prevent these outcomes there is an urgent need to develop …