The WW domain‐containing oxidoreductase (WWOX) gene is located at 16q23. 1–16q23. 2,
a region that spans the second most common human fragile site, FRA16D. The WWOX …

Expression of the WWOX gene, encompassing the common chromosome fragile site
FRA16D, is altered in a large fraction of cancers of various types, including prostate cancer …

The WW domain–containing oxidoreductase (WWOX) gene is located at FRA16D, a
common fragile site involved in human cancer. Targeted deletion of Wwox in mice causes …

The WWOX gene encodes a candidate tumor suppressor protein (WWOX) implicated in a
variety of human diseases such as cancer. To better understand the molecular mechanisms …

WWOX, the gene that maps to common chromosomal fragile site FRA16D, is frequently
affected by aberrations in multiple types of cancers. WWOX encodes a 46 kDa protein that …

Background Homozygous mutations in WWOX were reported in eight individuals of two
families with autosomal recessive spinocerebellar ataxia type 12 and in two siblings with …

WWOX is a cancer gene, spanning the common chromosomal fragile site 16D. Genomic and
expression aberrations affecting this gene and locus are common in various neoplasias …

Aphidicolin-induced common fragile sites are site-specific gaps or breaks seen on
metaphase chromosomes after partial inhibition of DNA synthesis. These fragile sites were …

Background The putative tumor suppressor WWOX gene spans the common chromosomal
fragile site 16D (FRA16D) at chromosome area 16q23. 3-24.1. This region is a frequent …

Mutations in the WWOX gene cause a broad range of ultra-rare neurodevelopmental and
brain degenerative disorders, associated with a high likelihood of premature death in animal …