The cerebellum plays a key role in movement control and in cognition and cerebellar
involvement is described in several neurodegenerative diseases. While conventional …

Purpose To assess the potential of histogram metrics of diffusion-tensor imaging (DTI)-
derived indices in revealing neurodegeneration and its progression in spinocerebellar …

Many patients with spinocerebellar ataxia (SCA) suffer from diverse neuropsychiatric issues,
including memory impairments, apathy, depression, or anxiety. These neuropsychiatric …

The clinical spectrum of spinocerebellar ataxia type 2 includes motor manifestations and
cognitive disturbances in executive functions, memory, and visuoconstructive skills. The …

Objective White matter (WM) integrity of Spinocerebellar ataxia 2 (SCA2) is poorly
understood, more so in the early stages of SCA2. In this study, we evaluated the …

Hereditary ataxias are a heterogeneous group of disorders characterized by degeneration of
the cerebellum and its connections. It is known that patients with ataxia can manifest a broad …

Abstract Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative
disease characterized by a progressive cerebellar syndrome and multiple-domain cognitive …

There is a clinically unmet need for a neuropsychological tool that reflects the
pathophysiology of cognitive dysfunction in cerebellar degeneration. We investigated …

Purpose Spinocerebellar ataxia type 2 (SCA2) is a progressive neurodegenerative disorder
characterized by cerebellar atrophy. However, studies to elucidate the longitudinal …

AIM To assess the burden of white matter (WM) damage in the cerebrum and cerebellum of
spinocerebellar ataxia type 2 (SCA2) patients in an attempt to identify key regions affected …