Airway smooth muscle (ASM) manifests a hyperresponsive phenotype in airway disorders
such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Current …

Cardiovascular disease (CVD) is an important comorbidity in a number of chronic
inflammatory diseases. However, evidence in highly prevalent respiratory disease such as …

Several mAbs have been tested or are currently under clinical evaluation for the treatment of
COPD. They can be subdivided into those that aim to block specific pro-inflammatory and …

Background Biologic agents may pose a potential risk for exacerbations of pulmonary
comorbidities in rheumatoid arthritis (RA) patients. Methods Using US Medicare and Truven …

In addition to hyperresponsiveness in asthma, airway smooth muscle (ASM) also manifests
an inflammatory phenotype characterized by augmented expression of mediators that …

BACKGROUND There is a growing evidence regarding an increased risk of inflammatory
bowel disease (IBD) among patients with airway diseases. AIM To investigate the influence …

The global prevalence of chronic obstructive pulmonary disease (COPD) has increased over
the last decade and has emerged as the third leading cause of death worldwide. It is …

Airway mucus secretion is an essential innate immune response for host protection.
However, overproduction and hypersecretion of mucus, mainly composed of MUC5AC, are …

Aims/hypothesis Increased renal mast cells have been detected in diabetic nephropathy.
However, only a few patients have been examined. Evidence of the involvement of mast …

Eosinophils play a central role in asthma. The present study was performed to investigate
the effect of tumour necrosis factor-α (TNF-α) on longevity of isolated human eosinophils. In …