Peripheral markers of depression

A Nobis, D Zalewski, N Waszkiewicz - Journal of clinical medicine, 2020 - mdpi.com
Major Depressive Disorder (MDD) is a leading cause of disability worldwide, creating a high
medical and socioeconomic burden. There is a growing interest in the biological …

Depression as a microglial disease

R Yirmiya, N Rimmerman, R Reshef - Trends in neurosciences, 2015 - cell.com
Despite decades of intensive research, the biological mechanisms that causally underlie
depression are still unclear, and therefore the development of novel effective antidepressant …

A review of depression and suicide risk assessment using speech analysis

N Cummins, S Scherer, J Krajewski, S Schnieder… - Speech …, 2015 - Elsevier
This paper is the first review into the automatic analysis of speech for use as an objective
predictor of depression and suicidality. Both conditions are major public health concerns; …

Treatment-resistant depression and peripheral C-reactive protein

SR Chamberlain, J Cavanagh, P De Boer… - The British Journal of …, 2019 - cambridge.org
BackgroundC-reactive protein (CRP) is a candidate biomarker for major depressive disorder
(MDD), but it is unclear how peripheral CRP levels relate to the heterogeneous clinical …

The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression

YK Kim, KS Na, AM Myint, BE Leonard - Progress in Neuro …, 2016 - Elsevier
Cytokines are pleiotropic molecules with important roles in inflammatory responses. Pro-
inflammatory cytokines and neuroinflammation are important not only in inflammatory …

Blood-brain barrier regulation in psychiatric disorders

J Kealy, C Greene, M Campbell - Neuroscience letters, 2020 - Elsevier
The blood-brain barrier (BBB) is a dynamic interface between the peripheral blood supply
and the cerebral parenchyma, controlling the transport of material to and from the brain …

Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer

W Chen, F Liu, Z Ling, X Tong, C Xiang - PloS one, 2012 - journals.plos.org
Recent reports have suggested the involvement of gut microbiota in the progression of
colorectal cancer (CRC). We utilized pyrosequencing based analysis of 16S rRNA genes to …

MMP‐9 in translation: from molecule to brain physiology, pathology, and therapy

B Vafadari, A Salamian… - Journal of …, 2016 - Wiley Online Library
Abstract Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …

The blood–brain barrier in psychosis

TA Pollak, S Drndarski, JM Stone, AS David… - The Lancet …, 2018 - thelancet.com
Blood–brain barrier pathology is recognised as a central factor in the development of many
neurological disorders, but much less is known about the role of the blood–brain barrier in …

Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis

SP Leighton, L Nerurkar, R Krishnadas… - Molecular …, 2018 - nature.com
Inflammatory illness is associated with depression. Preclinical work has shown that
chemokines are linked with peripheral–central crosstalk and may be important in mediating …