[HTML][HTML] Experimental murine models for colorectal cancer research

Í Neto, J Rocha, MM Gaspar, CP Reis - Cancers, 2023 - mdpi.com
Simple Summary In its early stages, colorectal cancer (CRC) is a localized tumor, but when it
metastasizes, it has dramatic consequences. Murine models in CRC research are important …

Prevention of carcinogenesis and metastasis by Artemisinin-type drugs

ML Abba, N Patil, JH Leupold, MEM Saeed, T Efferth… - Cancer letters, 2018 - Elsevier
Artemisia annua (sweet wormwood, qinhao) is an ancient Chinese herbal remedy for
pyrexia. Nowadays, artemisinin (qinghaosu) and its derivatives belong to the standard …

Quercetin attenuated oxidative DNA damage through NRF2 signaling pathway in rats with DMH induced colon carcinogenesis

SG Darband, S Sadighparvar, B Yousefi, M Kaviani… - Life Sciences, 2020 - Elsevier
Accumulating recent studies have demonstrated the preventive and therapeutic effects of
polyphonic compounds such as quercetin in colorectal cancer. Therefore, we aimed to …

[HTML][HTML] Efficacy of ivermectin against colon cancer induced by dimethylhydrazine in male wistar rats

HA Alghamdi, M Al-Zharani, NH Aljarba… - Saudi Pharmaceutical …, 2022 - Elsevier
Colon cancer (CC) is a common form of cancer worldwide. According to growing incidence
of cancer and little information about the possible protective role of Ivermectin (IVM) on colon …

[HTML][HTML] Ivermectin ameliorate the toxic effect of dimethylhydrazine in male Wistar rats

M Al-Zharani, HA Alghamdi, BA Aldahmash… - Journal of King Saud …, 2022 - Elsevier
Cancer is emerging as one of the most significant challenges to the human health.
Ivermectin (IVM) is one of the most effective drugs in veterinary and human medicine. The …

The third pathway of colorectal carcinogenesis

CA Rubio, G Puppa, G de Petris, L Kis… - Journal of clinical …, 2018 - jcp.bmj.com
Aims The majority of the colorectal carcinomas (CRC) arise in a vast mucosal area built with
columnar cells and mucus-producing goblet cells. These carcinomas evolve via the …

An overview of chemically induced rodent models for sporadic colorectal cancer: Histopathological and translational perspectives

LM Sarmiento Machado, MA Marchesan Rodrigues… - 2024 - digitum.um.es
Globally, colorectal cancer (CRC) is one of the most frequently diagnosed human
gastrointestinal neoplasia and the second leading cause of cancer-related death in both …

[HTML][HTML] Corrupted colonic crypt fission in carcinogen-treated rats

CA Rubio - PLoS One, 2017 - journals.plos.org
Background The colonic crypts in rats reproduce themselves by symmetric fission at the
base of the crypts, and proceeding upwards, generate two separate identical crypts …

[HTML][HTML] Design, optimization and validation of genes commonly used in expression studies on DMH/AOM rat colon carcinogenesis model

D Bars-Cortina, A Riera-Escamilla, G Gou… - PeerJ, 2019 - peerj.com
Colorectal cancer (CRC), also known as colon cancer, is the third most common form of
cancer worldwide in men and the second in women and is characterized by several genetic …

Are corrupted non-dysplastic colonic crypts the first histological event in experimental colonic carcinogenesis?

CA Rubio - Anticancer Research, 2017 - ar.iiarjournals.org
Background: The colonic crypts in rats replicate by symmetric fission at the base of the
crypts, and proceeds upwards, to generate two separate identical crypts. Recently …