Emerging role of aging in the progression of NAFLD to HCC

Y He, Y Su, C Duan, S Wang, W He, Y Zhang… - Ageing Research …, 2023 - Elsevier
With the aging of global population, the incidence of nonalcoholic fatty liver disease
(NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a …

Hepatic insulin receptor: new views on the mechanisms of liver disease

WH Lee, SM Najjar, CR Kahn, TD Hinds Jr - Metabolism, 2023 - Elsevier
Over 65% of people with obesity display the metabolic-associated fatty liver disease
(MAFLD), which can manifest as steatohepatitis, fibrosis, cirrhosis, or liver cancer. The …

[HTML][HTML] Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments

L Petagine, MG Zariwala, VB Patel - World Journal of …, 2023 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) causes significant global disease burden and is a
leading cause of mortality. NAFLD induces a myriad of aberrant changes in hepatocytes at …

Advances and perspectives in fluorescent probes for imaging hepatopathy-related biomarkers

W Quan, W Song, Q Zhang, H Huang, W Lin - Coordination Chemistry …, 2023 - Elsevier
As the metabolic and detoxification center of the body, the liver is closely involved in many
critical physiological processes, such as metabolism, immunity, digestion, storage of liver …

[HTML][HTML] Peroxisome proliferator-activated receptors as targets to treat metabolic diseases: Focus on the adipose tissue, liver, and pancreas

H Souza-Tavares, CS Miranda… - World Journal of …, 2023 - ncbi.nlm.nih.gov
The world is experiencing reflections of the intersection of two pandemics: Obesity and
coronavirus disease 2019. The prevalence of obesity has tripled since 1975 worldwide …

Carbon Monoxide: A Second Biomarker to Couple with Viscosity for the Construction of “Dual-Locked” Near-Infrared Fluorescent Probes for Accurately Diagnosing …

S Han, Y Zeng, Y Li, H Li, L Yang, X Ren… - Analytical …, 2023 - ACS Publications
Nonalcoholic fatty liver disease (NAFLD) can progress to cirrhosis and liver cancer if left
untreated. Therefore, it is of great importance to develop useful tools for the noninvasive and …

[HTML][HTML] Oxidative stress and microRNAs in endothelial cells under metabolic disorders

M Minjares, W Wu, JM Wang - Cells, 2023 - mdpi.com
Reactive oxygen species (ROS) are radical oxygen intermediates that serve as important
second messengers in signal transduction. However, when the accumulation of these …

[HTML][HTML] Recent insights into the biomarkers, molecular targets and mechanisms of non-alcoholic steatohepatitis-driven hepatocarcinogenesis

A Kakehashi, S Suzuki, H Wanibuchi - Cancers, 2023 - mdpi.com
Simple Summary This review is focused on the research recently published in the field of
non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver …

[HTML][HTML] The interconnection between hepatic insulin resistance and metabolic dysfunction-associated steatotic liver disease—the transition from an adipocentric to …

M Vesković, N Šutulović, D Hrnčić… - Current issues in …, 2023 - mdpi.com
The central mechanism involved in the pathogenesis of MAFLD is insulin resistance with
hyperinsulinemia, which stimulates triglyceride synthesis and accumulation in the liver. On …

[HTML][HTML] Non-Alcoholic Fatty Liver Disease Is Associated with a Decreased Catalase (CAT) Level, CT Genotypes and the T Allele of the -262 C/T CAT Polymorphism

M Kosmalski, I Szymczak-Pajor, J Drzewoski… - Cells, 2023 - mdpi.com
Background: It is well known that oxidative stress plays an important role in the development
of non-alcoholic fatty liver disease (NAFLD). It has been suggested that an insufficient …