Hepatitis B virus X protein promotes MAN1B1 expression by enhancing stability of GRP78 via TRIM25 to facilitate hepatocarcinogenesis

H You, N Zhang, T Yu, L Ma, Q Li, X Wang… - British Journal of …, 2023 - nature.com
Background GRP78 has been implicated in hepatocarcinogenesis. However, the clinical
relevance, biological functions and related regulatory mechanisms of GRP78 in hepatitis B …

[HTML][HTML] Innate and adaptive immune escape mechanisms of hepatitis B virus

HJ Zhao, YF Hu, QJ Han, J Zhang - World Journal of …, 2022 - ncbi.nlm.nih.gov
Chronic hepatitis B virus (HBV) infection is an international health problem with extremely
high mortality and morbidity rates. Although current clinical chronic hepatitis B (CHB) …

[HTML][HTML] TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity

W Fan, KB Mar, L Sari, IK Gaszek, Q Cheng, BM Evers… - Cell, 2021 - cell.com
To control viral infection, vertebrates rely on both inducible interferon responses and less
well-characterized cell-intrinsic responses composed of" at the ready" antiviral effector …

[HTML][HTML] Role of hepatitis B virus non-structural protein HBx on HBV replication, interferon signaling, and hepatocarcinogenesis

F Wang, H Song, F Xu, J Xu, L Wang, F Yang… - Frontiers in …, 2023 - frontiersin.org
Hepatitis B, a global health concern caused by the hepatitis B virus (HBV), infects nearly 2
billion individuals worldwide, as reported by the World Health Organization (WHO). HBV, a …

[HTML][HTML] Antiviral activity of interferon alpha-inducible protein 27 against hepatitis B virus gene expression and replication

H Ullah, M Sajid, K Yan, J Feng, M He… - Frontiers in …, 2021 - frontiersin.org
Despite the availability of effective vaccines, hepatitis B virus (HBV) is still a major health
issue, and approximately 350 million people have been chronically infected with HBV …

Mechanism of interferon alpha therapy for chronic hepatitis B and potential approaches to improve its therapeutic efficacy

Q Zhao, H Liu, L Tang, F Wang, G Tolufashe, J Chang… - Antiviral research, 2023 - Elsevier
Hepatitis B virus (HBV) chronically infects 296 million people worldwide and causes more
than 820,000 deaths annually due to cirrhosis and hepatocellular carcinoma. Current …

[HTML][HTML] Hepatitis B x antigen (HBx) is an important therapeutic target in the pathogenesis of hepatocellular carcinoma

A Medhat, A Arzumanyan, MA Feitelson - Oncotarget, 2021 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) is a human pathogen that has infected an estimated two billion
people worldwide. Despite the availability of highly efficacious vaccines, universal screening …

Snakehead vesiculovirus hijacks SH3RF1 for replication via mediating K63-linked ubiquitination at K264 of the phosphoprotein

X Qin, N Jiang, J Zhu, YA Zhang, J Tu - International Journal of Biological …, 2024 - Elsevier
Snakehead vesiculovirus (SHVV) is a type of rhabdovirus that causes serious economic
losses in snakehead fish culture in China. However, no specific antiviral drugs or vaccines …

TRIM26 inhibits hepatitis B virus replication by promoting HBx degradation and TRIM26 genetic polymorphism predicts PegIFNα treatment response of HBeAg …

M Luo, J Hou, H Mai, J Chen, H Chen… - Alimentary …, 2022 - Wiley Online Library
Summary Background Hepatitis B virus (HBV) infection is a serious global health burden.
TRIM26 has been reported to affect hepatitis C virus replication. Aims To manifest the role of …

Mitochondrial glycerol-3-phosphate dehydrogenase restricts HBV replication via the TRIM28-mediated degradation of HBx

C Liu, K Zhao, Y Chen, Y Yao, J Tang, J Wang… - Journal of …, 2023 - Am Soc Microbiol
Hepatitis B virus (HBV) infection affects hepatic metabolism. Serum metabolomics studies
have suggested that HBV possibly hijacks the glycerol-3-phosphate (G3P) shuttle. In this …