Mitochondrial glycerol-3-phosphate dehydrogenase restricts HBV replication via the TRIM28-mediated degradation of HBx

C Liu, K Zhao, Y Chen, Y Yao, J Tang, J Wang… - Journal of …, 2023 - Am Soc Microbiol
Hepatitis B virus (HBV) infection affects hepatic metabolism. Serum metabolomics studies
have suggested that HBV possibly hijacks the glycerol-3-phosphate (G3P) shuttle. In this …

TRIM31: A molecule with a dual role in cancer

Y Guo, P Lin, Y Hua, C Wang - Frontiers in oncology, 2022 - frontiersin.org
Tripartite motif (TRIM) 31 is a new member of the TRIM family and functions as an E3
ubiquitin ligase. Abnormal TRIM31 expression leads to a variety of pathological conditions …

Impact of hepatitis B virus genetic variation, integration, and lymphotropism in antiviral treatment and oncogenesis

KCK Lau, KW Burak, CS Coffin - Microorganisms, 2020 - mdpi.com
Chronic Hepatitis B Virus (HBV) infection poses a significant global health burden. Although,
effective treatment and vaccinations against HBV are available, challenges still exist …

Role of epigenetic modification in interferon treatment of hepatitis B virus infection

Z Yang, B Sun, J Xiang, H Wu, S Kan, M Hao… - Frontiers in …, 2022 - frontiersin.org
Human hepatitis B virus (HBV) is a small, enveloped DNA virus that causes acute and
chronic hepatitis. Chronic hepatitis B (CHB) is associated with hepatocellular carcinoma …

Hepatitis B virus X protein and its host partners

H Song, F Xu, Q Xiao, G Tan - Cellular & Molecular Immunology, 2021 - nature.com
Hepatitis B virus (HBV) is a widespread human pathogen, especially in China, and is known
to cause liver inflammation, cirrhosis, and hepatocellular carcinoma. A total of ten different …

Transcriptional regulation and signaling of type IV IFN with identification of the ISG repertoire in an amphibian model, Xenopus laevis

SN Chen, B Li, Z Gan, KL Wang, L Li… - The Journal of …, 2023 - journals.aai.org
Abstract The type IV IFN (IFN-υ) is reported in vertebrates from fish to primary mammals with
IFN-υR1 and IL-10R2 as receptor subunits. In this study, the proximal promoter of IFN-υ was …

TRIM25 inhibits HBV replication by promoting HBx degradation and the RIG-I-mediated pgRNA recognition

H Song, Q Xiao, F Xu, Q Wei, F Wang… - Chinese Medical …, 2023 - mednexus.org
Background: The hepatitis B virus (HBV) vaccine has been efficiently used for decades.
However, hepatocellular carcinoma caused by HBV is still prevalent globally. We previously …

Dual-Role of Cholesterol‐25‐Hydroxylase in Regulating Hepatitis B Virus Infection and Replication

Q Wei, H Song, Y Gao, F Xu, Q Xiao, F Wang, B Lei… - Mbio, 2022 - Am Soc Microbiol
Hepatitis B virus (HBV)‐related diseases are among the major diseases that affect millions
of people worldwide. These diseases are difficult to eradicate and thus pose a serious …

LINC01431 promotes histone H4R3 methylation to impede HBV covalently closed circular DNA transcription by stabilizing PRMT1

Y Sun, Y Teng, L Wang, Z Zhang, CJ Chen… - Advanced …, 2022 - Wiley Online Library
Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus
(HBV), which interacts with both host and viral proteins to form minichromosome in the …

NEDD4 induces K48-linked degradative ubiquitination of hepatitis B virus X protein and inhibits HBV-associated HCC progression

T Wan, Z Lei, B Tu, T Wang, J Wang, F Huang - Frontiers in Oncology, 2021 - frontiersin.org
Neural precursor cell expressed developmentally downregulated gene 4 (NEDD4) plays two
opposite roles in carcinogenesis. It has been reported that NEDD4 inhibits hepatocellular …