Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex
F Deng, G Xu, Z Cheng, Y Huang, C Ma, C Luo… - Frontiers in …, 2021 - frontiersin.org
Chronic hepatitis B is a major health problem worldwide, with more than 250 million chronic
carriers. Hepatitis B virus interferes with the host innate immune system so as to evade …
carriers. Hepatitis B virus interferes with the host innate immune system so as to evade …
Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA
D Wang, D Wang, M Huang, X Zheng… - Journal of Molecular …, 2021 - academic.oup.com
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection, has become a global public health crisis …
syndrome coronavirus 2 (SARS-CoV-2) infection, has become a global public health crisis …
Type-III interferon stimulated gene TRIM31 mutation in an HBV patient blocks its ability in promoting HBx degradation
F Xu, H Song, Q Xiao, Q Wei, X Pang, Y Gao, G Tan - Virus Research, 2022 - Elsevier
TRIM5γ, together with TRIM31, has been shown to promote HBx ubiquitination and
degradation. This study aimed to explore whether a patient with HCC (hepatic cell …
degradation. This study aimed to explore whether a patient with HCC (hepatic cell …
Rapamycin inhibits hepatitis B virus covalently closed circular DNA transcription by enhancing the ubiquitination of HBx
Y Zhang, L Li, ST Cheng, YP Qin, X He, F Li… - Frontiers in …, 2022 - frontiersin.org
Hepatitis B virus (HBV) infection is still a serious public health problem worldwide. Antiviral
therapies such as interferon and nucleos (t) ide analogs efficiently control HBV replication …
therapies such as interferon and nucleos (t) ide analogs efficiently control HBV replication …
[HTML][HTML] E3 ubiquitin ligase TRIM31: A potential therapeutic target
NH Deng, Z Tian, YJ Zou, SB Quan - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Ubiquitination is a key mechanism for post-translational protein modification, affecting
protein localization, metabolism, degradation and various cellular physiological processes …
protein localization, metabolism, degradation and various cellular physiological processes …
[HTML][HTML] Hepatitis B Viral Protein HBx: Roles in Viral Replication and Hepatocarcinogenesis
D Li, Y Hamadalnil, T Tu - Viruses, 2024 - mdpi.com
Hepatitis B virus (HBV) infection remains a major public health concern worldwide, with
approximately 296 million individuals chronically infected. The HBV-encoded X protein …
approximately 296 million individuals chronically infected. The HBV-encoded X protein …
[HTML][HTML] Baicalin inhibits the replication of the hepatitis B virus by targeting TRIM25
X Fan, F Wang, H Song, F Xu, X Li, Q Wei, B Lei… - Journal of Traditional …, 2023 - Elsevier
Objective Baicalin, which is a key bioactive constituent obtained from Scutellaria
baicalensis, has been utilized in traditional Chinese medicine for many centuries. Although it …
baicalensis, has been utilized in traditional Chinese medicine for many centuries. Although it …
[HTML][HTML] The Role of Tripartite Motif Family Proteins in Chronic Liver Diseases: Molecular Mechanisms and Therapeutic Potential
X Cao, Y Chen, Y Chen, M Jiang - Biomolecules, 2024 - mdpi.com
The worldwide impact of liver diseases is increasing steadily, with a consistent upswing
evidenced in incidence and mortality rates. Chronic liver diseases (CLDs) refer to the liver …
evidenced in incidence and mortality rates. Chronic liver diseases (CLDs) refer to the liver …
Tripartite Motif-Containing Protein 65 (TRIM65) Inhibits Hepatitis B Virus Transcription
Tripartite motif (TRIM) proteins, comprising a family of over 100 members with conserved
motifs, exhibit diverse biological functions. Several TRIM proteins influence viral infections …
motifs, exhibit diverse biological functions. Several TRIM proteins influence viral infections …
[HTML][HTML] High-throughput screening strategies for space-based radiation countermeasure discovery
As humanity begins to venture further into space, approaches to better protect astronauts
from the hazards found in space need to be developed. One particular hazard of concern is …
from the hazards found in space need to be developed. One particular hazard of concern is …