Targeted protein degradation has emerged in recent years as a powerful new modality in
drug discovery. A major challenge in antiviral research is to identify drugs that target disease …

Hepatitis B virus (HBV) infection is closely associated with the adverse events such as liver
cirrhosis, liver cancer, and liver failure and remains a serious threat to human health …

The work included in this PhD thesis was performed, designed, and written by Keith Chi Kei
Lau at the University of Calgary, Calgary, Alberta, Canada under the supervision of Dr. Carla …