IGF-I is a multipotent growth factor with important actions on normal tissue growth and
regeneration. In addition, IGF-I has been suggested to have beneficial effects on glucose …

Growth hormone deficiency (GHD) is a clinical syndrome that can manifest either as isolated
or associated with additional pituitary hormone deficiencies. Although diminished height …

THOMAS A. WILSON, MD, SUSAN R. ROSE, MD, PINCHAS COHEN, MD, ALAN D. ROGOL,
MD, PHD, PHILIPPE BACKELJAUW, MD, ROSALIND BROWN, MD, DANA S. HARDIN, MD …

Short stature remains the most common reason for referral to a pediatric Endocrinologist and
its management remains a challenge. One of the main controversies is the diagnosis of …

Albright hereditary osteodystrophy (AHO) is a genetic disorder caused by heterozygous
inactivating mutations in GNAS1, the gene encoding the α-chain of Gs, and is associated …

Advances in molecular biology have led to the identification of mutations within several
novel genes associated with the phenotype of isolated growth hormone deficiency …

Based on a recent Dutch national guideline, we propose a structured stepwise diagnostic
approach for children with growth failure (short stature and/or growth faltering), aiming at …

Objectives Provocative growth hormone (GH) tests are widely used for diagnosing pediatric
GH deficiency (GHD). A thorough understanding of the evidence behind commonly used …

Growth hormone (GH), also known as somatotropin, is a peptide hormone that is
synthesized and secreted by the somatotrophs of the anterior pituitary gland. The main …

Context: Severe congenital GH deficiency (GHD) of the newborn is a rare disease, which
can cause life-threatening hypoglycemias beginning in the first week of life. Reviews and …