It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of
insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to …

In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

Impaired insulin-mediated suppression of hepatic glucose production (HGP) plays a major
role in the pathogenesis of type 2 diabetes (T2D), yet the molecular mechanism by which …

The fertility and survival of an individual rely on the ability of the periphery to promptly,
effectively, and reproducibly communicate with brain neural networks that control …

Dieting is the most common approach to losing weight for the majority of obese and
overweight individuals. Restricting intake leads to weight loss in the short term, but, by itself …

This Review highlights the processing and integration performed by hindbrain nuclei,
focusing on the inputs received by nucleus tractus solitarius (NTS) neurons. These inputs …

Although a prominent role for the brain in glucose homeostasis was proposed by scientists
in the nineteenth century, research throughout most of the twentieth century focused on …

Weight regain after weight loss is a substantial challenge in obesity therapeutics. Dieting
leads to significant adaptations in the homeostatic system that controls body weight, which …

This review is focused on two topics related to glucose in vertebrates. In a first section
devoted to glucose homeostasis we describe how glucose levels fluctuate and are regulated …

Some 12 years ago, a polymorphism of the angiotensin I-converting enzyme (ACE) gene
became the first genetic element shown to impact substantially on human physical …