Existing and emerging treatments for idiopathic pulmonary fibrosis

L Kolilekas, S Papiris, D Bouros - Expert Review of Respiratory …, 2019 - Taylor & Francis
Introduction: Idiopathic pulmonary fibrosis (IPF) is a progressive and invariable fatal
interstitial lung disease. Current antifibrotic treatment halts disease progression but does not …

Identifying and managing sleep disorders in primary care

CL Chai-Coetzer, NA Antic… - The Lancet Respiratory …, 2015 - thelancet.com
Snoring, obesity, older age, and male gender are well known risk factors for OSA. Men have
a two-fold greater risk of OSA than premenopausal women but men and women are affected …

Novel treatments for idiopathic pulmonary fibrosis

P Spagnolo - The American journal of medicine, 2015 - amjmed.com
Idiopathic pulmonary fibrosis, the most common of the idiopathic interstitial pneumonias, is
an irreversible, unpredictable, and ultimately fatal disorder of unknown cause. 1 The …

[HTML][HTML] The Clinical efficacy of pulmonary hypertension-specific agents in idiopathic pulmonary fibrosis: systematic review and meta-analysis of randomized …

J Lee, JU Song - Journal of Korean Medical Science, 2020 - ncbi.nlm.nih.gov
Background Pulmonary hypertension (PH) is common in patients with idiopathic pulmonary
fibrosis (IPF) and is associated with poor outcomes. This study was performed to determine …

Clinical trials in IPF: what are the best endpoints?

P Spagnolo, E Cocconcelli, V Cottin - Idiopathic Pulmonary Fibrosis: A …, 2019 - Springer
Idiopathic pulmonary fibrosis (IPF), the most common and lethal of all chronic idiopathic
interstitial pneumonias, is a disease that is rare and is still regarded as an orphan condition …

Clinical trials in idiopathic pulmonary fibrosis in the “Posttreatment Era”

KF Gibson, DJ Kass - Jama, 2018 - jamanetwork.com
The “treatment era” for idiopathic pulmonary fibrosis (IPF) in the United States and other
countries was inaugurated in November 2014 following the Food and Drug Administration's …

Weak to no correlation between quantitative high-resolution computed tomography metrics and lung function change in fibrotic diseases

Y Zou, X Hou, N Anegondi, M Negahdar… - ERJ Open …, 2023 - Eur Respiratory Soc
Background Identifying systemic sclerosis (SSc) and idiopathic pulmonary fibrosis (IPF)
patients at risk of more rapid forced vital capacity (FVC) decline could improve trial design …

[HTML][HTML] Reduced sialylation and bioactivity of the antifibrotic protein serum amyloid P in the sera of patients with idiopathic pulmonary fibrosis

W Chen, TR Karhadkar, C Ryu, EL Herzog… - …, 2020 - journals.aai.org
Pulmonary fibrosis is a chronic and generally fatal disorder characterized by progressive
formation of scar-like tissue in the lungs. Sialic acids are often found as the terminal sugar …

Missing data in IPF trials: do not let methodological issues undermine a major therapeutic breakthrough

G Thabut, B Crestani, R Porcher… - European Respiratory …, 2015 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disorder associated with a poor
prognosis. Until recently, there has been limited evidence that any drug could alter the …

New therapeutic avenues for treatment of fibrosis: can we learn from other diseases?

G Rogler - Digestive Diseases, 2014 - karger.com
Crohn's disease (CD) is characterized by the frequent occurrence of complications, such as
fibrotic strictures and subsequently the need for CD-related surgery. Chronic or recurrent …