Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The
spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases …

BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …

The clinical effect of sperm DNA damage in assisted reproduction has been a controversial
topic during recent decades, leading to a variety of clinical practice recommendations. While …

Almost 50% of the infertility cases are due to male factors. Assisted reproductive
technologies (ARTs) allow to overcome the incapacity of these patients' spermatozoa to …

Based on the inconsistent literature published thus far involving infertile patients, whether
intracytoplasmic sperm injection (ICSI) allows overcoming total fertilization failure due to …

Objective To analyze the effect of single-and double-stranded sperm DNA fragmentation
(ssSDF and dsSDF) on human embryo kinetics monitored under a time-lapse system …

Sperm DNA damage is considered a predictive factor for the clinical outcomes of patients
undergoing ART. Laboratory evidence suggests that zygotes and developing embryos have …

Research question Spontaneous pregnancy loss affects 10–15% of couples, with 1–2%
suffering recurrent pregnancy loss and 50% of miscarriages remaining unexplained. Male …

Magnetic-activated cell sorting (MACS) can be used to separate apoptotic sperm with high
proportions of fragmented DNA from the rest, thus improving the overall quality of the …

Objective To better study the effect of sperm deoxyribonucleic acid fragmentation (SDF) on
intracytoplasmic sperm injection (ICSI) outcomes from an ovum donation program by …