Cancer immune evasion is a major stumbling block in designing effective anticancer
therapeutic strategies. Although considerable progress has been made in understanding …

Immunotherapy based on the adoptive transfer of naturally occurring or gene-engineered T
cells can mediate tumour regression in patients with metastatic cancer. Here, we discuss …

Despite the frequent detection of circulating tumor antigen–specific T cells, either
spontaneously or following active immunization or adoptive transfer, immune-mediated …

Great progress has been made in the field of tumor immunology in the past decade, but
optimism about the clinical application of currently available cancer vaccine approaches is …

The question of whether tumorigenic cancer stem cells exist in human melanomas has
arisen in the last few years. Here we show that in melanomas, tumour stem cells (MTSCs, for …

Synthetic oligonucleotides (ODN) that express unmethylated “CpG motifs” trigger cells that
express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells …

The canonical Wnt/β-catenin signaling pathway, an important modulator of progenitor cell
proliferation and differentiation, is highly regulated for the maintenance of critical biological …

Melanoma is the main cause of death in patients with skin cancer1. Cytotoxic T lymphocytes
(CTLs) attack melanoma cells in an HLA-restricted and tumor antigen-specific manner …

Publisher Summary It is known for some time that malignant transformation of human cells
may be associated with the appearance of tumor associated antigens (TAA). Decades of …

The cloning of the genes encoding cancer antigens has opened new possibilities for the
treatment of patients with cancer. In this study, immunodominant peptides from the gp100 …