Heterogeneity within a tumour increases its ability to adapt to constantly changing
constraints, but adversely affects a patient's prognosis, therapy response and clinical …

Cancer cells can organize and communicate in functional networks. Similarly to other
networks in biology and sociology, these can be highly relevant for growth and resilience. In …

Transcriptional heterogeneity among malignant cells of a tumor has been studied in
individual cancer types and shown to be organized into cancer cell states; however, it …

Many effective drugs for metastatic and/or advanced-stage cancers have been developed
over the past decade, although the evolution of resistance remains the major barrier to …

What do corruption, resource overexploitation, climate inaction, vaccine hesitancy, traffic
congestion, and even cancer metastasis have in common? All these socioeconomic and …

Most tumor treatments will fail when ignoring competition and cooperation between each
cancer cell and its microenvironment. Inspired by game theory, therapeutic agents can be …

Covering the major topics of evolutionary game theory, Game-Theoretical Models in Biology,
Second Edition presents both abstract and practical mathematical models of real biological …

Melanomas can have multiple coexisting cell states, including proliferative (PRO) versus
invasive (INV) subpopulations that represent a" go or grow" trade-off; however, how these …

Evolutionary game theory mathematically conceptualizes and analyzes biological
interactions where one's fitness not only depends on one's own traits, but also on the traits of …

The application of evolutionary and ecological principles to cancer prevention and
treatment, as well as recognizing cancer as a selection force in nature, has gained impetus …