The cardiac benefits of exercise have been recognized for centuries. Studies have
undisputedly shown that regular exercise is beneficial for the cardiovascular system in …

Abstract Cardiovascular (CV) disease (CVD) remains the leading cause of major morbidity
and CVD-and all-cause mortality in most of the world. It is now clear that regular physical …

Abstract Microplastics (MPs) and nanoplastics (NPs) are ubiquitous in the marine
environments due to the wide use and mismanagement of plastics. However, the effect of …

Age-related muscle wasting and dysfunction render the elderly population vulnerable and
incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the …

Skeletal muscle displays remarkable plasticity upon exercise and is also one of the organs
most affected by aging. Despite robust evidence that aging is associated with loss of fast …

Metabolic reprogramming is critical in the onset of pressure overload–induced cardiac
remodeling. Our study reveals that proline dehydrogenase (PRODH), the key enzyme in …

Reduction oxidation (REDOX) reaction is crucial in life activities, and its dynamic balance is
regulated by ROS. Reactive oxygen species (ROS) is associated with a variety of metabolic …

Despite substantial evidence emphasizing the pleiotropic benefits of exercise for the
prevention and treatment of various diseases, the underlying biological mechanisms have …

Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a neglected tropical
disease and a health problem in Latin America. Etiological treatment has limited …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with reduced
quality of life and earlier mortality, but its pathogenesis and key genes are still unclear. In …