The bigger picture: Why oral mucosa heals better than skin

M Waasdorp, BP Krom, FJ Bikker, PPM van Zuijlen… - Biomolecules, 2021 - mdpi.com
Wound healing is an essential process to restore tissue integrity after trauma. Large skin
wounds such as burns often heal with hypertrophic scarring and contractures, resulting in …

Scarless wound healing: current insights from the perspectives of TGF-β, KGF-1, and KGF-2

W Xiaojie, J Banda, H Qi, AK Chang, C Bwalya… - Cytokine & growth factor …, 2022 - Elsevier
The process of wound healing involves a complex and vast interplay of growth factors and
cytokines that coordinate the recruitment and interaction of various cell types. A series of …

The role of extracellular matrix in skin wound healing

NN Potekaev, OB Borzykh, GV Medvedev… - Journal of Clinical …, 2021 - mdpi.com
Impaired wound healing is one of the unsolved problems of modern medicine, affecting
patients' quality of life and causing serious economic losses. Impaired wound healing can …

New insights into balancing wound healing and scarless skin repair

S Zhou, M Xie, J Su, B Cai, J Li… - Journal of Tissue …, 2023 - journals.sagepub.com
Scars caused by skin injuries after burns, wounds, abrasions and operations have serious
physical and psychological effects on patients. In recent years, the research of scar free …

3D in vitro M2 macrophage model to mimic modulation of tissue repair

J Sapudom, S Karaman, WKE Mohamed… - npj Regenerative …, 2021 - nature.com
Distinct anti-inflammatory macrophage (M2) subtypes, namely M2a and M2c, are reported to
modulate the tissue repair process tightly and chronologically by modulating fibroblast …

Macrophages in healing wounds: paradoxes and paradigms

LA DiPietro, TA Wilgus, TJ Koh - International journal of molecular …, 2021 - mdpi.com
Macrophages are prominent cells in normally healing adult skin wounds, yet their exact
functions and functional significance to healing outcomes remain enigmatic. Many functional …

Reprograming the immune niche for skin tissue regeneration–from cellular mechanisms to biomaterials applications

R Mu, SC de Souza, Z Liao, L Dong, C Wang - Advanced Drug Delivery …, 2022 - Elsevier
Despite the rapid development of therapeutic approaches for skin repair, chronic wounds
such as diabetic foot ulcers remain an unaddressed problem that affects millions of people …

Biological glue from only lipoic acid for scarless wound healing by anti-inflammation and TGF-β regulation

C Liu, R Lu, M Jia, X Xiao, Y Chen, P Li… - Chemistry of …, 2023 - ACS Publications
Biological glue (bioglue) neatly and noninvasively seals wound against external tension and
holds great potential in scarless wound healing. Nevertheless, the current bioglues lack …

Fibrosis in burns: an overview of mechanisms and therapies

S Faour, M Farahat, A Aijaz… - American Journal of …, 2023 - journals.physiology.org
Scar development remains a common occurrence and a major healthcare challenge
affecting the lives of millions of patients annually. Severe injuries to the skin, such as burns …

Immune cells in cutaneous wound healing: a review of functional data from animal models

DM Chesko, TA Wilgus - International journal of molecular sciences, 2022 - mdpi.com
The healing of skin wounds involves the activation and recruitment of various immune cell
types, many of which are believed to contribute significantly to different aspects of the repair …